AI Article Synopsis
- Scientists studied baby animals born to normal moms and moms who had some of their kidneys removed.
- The babies born to the kidney-removed moms were lighter at first but didn't have changes in blood pressure.
- However, when the researchers kept fewer of these babies together, they started growing faster and showed changes that could make them at risk for health problems later on.
Article Abstract
Changes in body weight (BW), systolic blood pressure (SBP), and localization of renin in the kidneys of neonates born to normal mothers (C neonates) or to five-sixths (5/6) nephrectomized (2/3 left kidney and right kidney) mothers (Nx neonates) were studied. Maternal 5/6 nephrectomy caused weight loss in neonates but no differences in SBP or renin localization. Culling Nx neonates to a litter of 3 at 1 day after birth resulted in growth catching up with C neonates from 3 weeks old and increases in both SBP and renin-positive cells in neonatal kidney. These findings revealed that maternal 5/6 nephrectomy results in low-birth-weight neonates and that these neonates are at increased risk of metabolic syndrome by catch-up growth.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9523287 | PMC |
| http://dx.doi.org/10.1292/jvms.22-0025 | DOI Listing |
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