Orocoecal transit time was studied by means of a hydrogen (H2) breath test after a standard meal in patients with peptic disease before and during treatment with ranitidine, in patients with gastric achlorhydria, and in healthy acid-secreting volunteers. Treatment with ranitidine prolonged the orocoecal transit time in patients with peptic disease from 201.9 +/- 18.3 (SEM) to 242.3 +/- 18.3 min (p less than 0.05). Also in patients with achlorhydria, the orocoecal transit time was prolonged (276.2 +/- 20.3 min), compared to the control group of healthy acid-secreting volunteers (213.5 +/- 15.7 min), (p less than 0.05). The orocoecal transit time did not correlate with gastric bacterial concentrations in the groups investigated, nor with the subjects' age. It was not correlated to the pH in the gastric juice of acid-secreting individuals, either with or without treatment. As gastric emptying was not evaluated in this study, it is impossible to state whether gastric stasis or inhibited small bowel motility, or both, cause the delayed transit in achlorhydria and during treatment with ranitidine. We suggest that the reduction of gastric juice volume could be the cause.
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