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| http://dx.doi.org/10.1007/s10620-022-07628-z | DOI Listing |
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Emerging trends in designing polysaccharide based mucoadhesive network hydrogels as versatile platforms for innovative delivery of therapeutic agents: A review.
Int J Biol Macromol
January 2025
Department of Chemistry, Himachal Pradesh University, Shimla 171005, India. Electronic address:
Introduction: The rapid progress in polymer science has designed innovative materials for biomedical applications. In the case of drug design, for each new therapeutic agent, a drug delivery system (DDS) is required to improve its pharmacokinetic and pharmacodynamic parameters. Therefore, significant research has been carried out to develop drug delivery (DD) carriers for these new therapeutic agents.
View Article and Find Full Text PDFNanoparticle Carriers for Drug Delivery: An Updated Review.
Pharm Nanotechnol
December 2024
Lorestan University, Chemistry.
The drug was initially administrated relying on pills, eye drops, ointments, and intravenous solutions. In the last decades, several novel technologies have emerged to overcome significant challenges including poor solubility, drug aggregation, low bioavailability, limited biodistribution, poor absorption in the body, lack of selectivity, or to minimize the adverse effects of therapeutic drugs. Drug delivery systems (DDS) can be designed to the technologies that carry drugs into or throughout the body of humans or animals to enhance therapeutic efficacy.
View Article and Find Full Text PDFSystematic review: Mechanisms of photoactive nanocarriers for imaging and therapy including controlled drug delivery.
Eur J Nucl Med Mol Imaging
December 2024
Department of Biomedical Engineering, Michigan State University, East Lansing, MI, 48824, USA.
Background: The design of smart, photoactivated nanomaterials for targeted drug delivery systems (DDS) has garnered significant research interest due in part to the ability of light to precisely control drug release in specific cells or tissues with high spatial and temporal resolution. The development of effective light-triggered DDS involves mechanisms including photocleavage, photoisomerization, photopolymerization, photosensitization, photothermal phenomena, and photorearrangement, which permit response to ultraviolet (UV), visible (Vis), and/or Near Infrared (NIR) light. This review explores recent advancements in light-responsive small molecules, polymers, and nanocarriers, detailing their underlying mechanisms and utility for drug delivery and/or imaging.
View Article and Find Full Text PDFAssessment of operator performance during dynamically guided osteotomy and root-end resection in endodontic microsurgery: A cross-sectional in vitro study.
J Dent
February 2025
Faculty of Dentistry, DDS, Mdent, Graduate Endodontics Program, University of Antioquia, Medellín, Colombia; Faculty of Dentistry, DDS, Mdent, Graduate Oral and Maxillofacial Program, University of Antioquia, Medellín, Colombia. Electronic address:
Article Synopsis
- - The study aimed to evaluate how the experience level of two operators affects their performance and accuracy when using computer-assisted dynamic navigation (C-ADN) systems during dental procedures involving thick bone layers, specifically in osteotomy and root-end resections.
- - Results indicated that the less experienced operator exhibited significantly worse performance in terms of task-focused metrics, including longer visuomotor coordination times and higher rates of procedural errors compared to the experienced operator, who showed better overall outcomes.
- - Both operators felt that C-ADN systems improved their surgical skills and patient safety, but only the less experienced operator reported challenges related to mental workload and usability, highlighting a gap in proficiency and comfort with the technology.
A Perspective on the Use of Hydroxyapatites to Improve the Dissolution Behavior of Poorly Water-Soluble Piretanide.
Pharmaceutics
November 2024
Department of Chemistry, University of Pavia, viale Taramelli 16, 27100 Pavia, Italy.
Background/objectives: Interest in drug delivery systems (DDS) based on inorganic substrates has increased in parallel with the increase in the number of poorly water-soluble drugs. Hydroxyapatite is one of the ideal matrices for DDS due to its biocompatibility, low cost, and ease of preparation.
Methods: We propose two doped hydroxyapatites, one with Ba on Ca sites another with Si on P sites, with the aim of improving the dissolution rate of piretanide, a diuretic, poorly water-soluble drug.
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