AI Article Synopsis
- Studies are needed to assess the safety and effectiveness of mRNA vaccines in pregnant individuals and how well antibodies are passed to newborns.
- A study involving 20 individuals vaccinated late in pregnancy found no mRNA vaccine products in maternal or neonatal blood, but confirmed the efficient transfer of protective antibodies to newborns.
- The timing of vaccination is important for ensuring that mothers can provide effective antibody protection to their infants through the placenta.
Article Abstract
Studies are needed to evaluate the safety and effectiveness of mRNA SARS-CoV-2 vaccination during pregnancy, and the levels of protection provided to their newborns through placental transfer of antibodies. Here, we evaluate the transplacental transfer of mRNA vaccine products and functional anti-SARS-CoV-2 antibodies during pregnancy and early infancy in a cohort of 20 individuals vaccinated during late pregnancy. We find no evidence of mRNA vaccine products in maternal blood, placenta tissue, or cord blood at delivery. However, we find time-dependent efficient transfer of IgG and neutralizing antibodies to the neonate that persists during early infancy. Additionally, using phage immunoprecipitation sequencing, we find a vaccine-specific signature of SARS-CoV-2 Spike protein epitope binding that is transplacentally transferred during pregnancy. Timing of vaccination during pregnancy is critical to ensure transplacental transfer of protective antibodies during early infancy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338928 | PMC |
| http://dx.doi.org/10.1038/s41467-022-32188-1 | DOI Listing |
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