Adding duborimycin to the association of vincristine + DTIC in the treatment of malignant melanoma produces therapeutic results interesting but not statistically significant and not counter-balancing the toxic side effects. This study confirms the lack of positive results of polychemotherapy in melanoma as compared to treatment by an efficacious single drug therapy (DTIC); it also emphasizes the necessity of randomized studies so that valuable comparisons may be done.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Nuclear N-WASP Induces Actin Polymerization in the Nucleus with Cortactin as an Essential Factor.
Cells
January 2025
Biotech Research and Innovation Center (BRIC), University of Copenhagen, Ole Maaløes Vej5, 2200 Copenhagen, Denmark.
Nuclear actin polymerization was reported to control different nuclear processes, but its regulation is poorly understood. Here, we show that N-WASP can trigger the formation of nuclear N-WASP/F-actin nodules. While a cancer hotspot mutant of N-WASP lacking the VCA domain (V418fs) had a dominant negative function on nuclear F-actin, an even shorter truncation mutant found in melanoma (R128*) strongly promoted nuclear actin polymerization.
View Article and Find Full Text PDFBlack posterior vitreous detachment: A 10-year historical cohort of pigmented uveal tumors.
Heliyon
January 2025
Faculty of Medical and Health Sciences, Tel Aviv University, Israel.
Objective: Pigmentary posterior vitreous detachment (PVD), referred to as "black PVD," is a rare entity describing PVD along with pigment dispersion in the vitreous. There are a few case reports describing pigmentary PVD, yet the association between pigmentary PVD and uveal and optic disc tumors was not described before. The aim of this study was to report the clinical features of patients with pigmentary PVD associated with these tumors.
View Article and Find Full Text PDFDiagnostic performance of generative pretrained transformer -4 with vision technology versus board-certified dermatologists: A comparative analysis using dermoscopic and clinical images.
JAAD Int
February 2025
Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York.
Amyopathic Dermatomyositis with a Rapidly Progressing Interstitial Pneumonia.
Eur J Case Rep Intern Med
November 2024
Department of Lung Diseases and Thoracic Surgery, Pauls Stradins Clinical University Hospital, Riga, Latvia.
Background: Clinically amyopathic dermatomyositis (CADM) is a rare subtype of idiopathic inflammatory myositis often linked with the presence of autoantibodies targeting melanoma differentiation-associated protein 5 (MDA5). Patients with CADM are at increased risk of developing rapidly progressing interstitial lung disease, which significantly increases both morbidity and mortality compared to other forms of inflammatory myopathies. While there is no standardized treatment regimen, current therapeutic strategies are generally focused on combination immunosuppressive therapies.
View Article and Find Full Text PDFResearch progress of Chinese medicinal monomers in the process of melanoma occurrence.
Pharm Biol
December 2025
Department of Pathophysiology, Zunyi Medical University, Zunyi, China.
Context: Melanoma's aggressiveness and resistance to radiotherapy highlight an urgent need for innovative treatments. Traditional Chinese medicine (TCM) offers a unique approach through its 'four natures' theory-cold, cool, warm, and hot.
Objective: This review aims to explore the potential of TCM's 'four natures' herbal monomers in melanoma treatment, providing an alternative to conventional therapies.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!