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Reduction in Renal Heme Oxygenase-1 Is Associated with an Aggravation of Kidney Injury in Shiga Toxin-Induced Murine Hemolytic-Uremic Syndrome.
Toxins (Basel)
December 2024
Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Am Klinikum 1, 07747 Jena, Germany.
Hemolytic-uremic syndrome (HUS) is a systemic complication of an infection with Shiga toxin (Stx)-producing enterohemorrhagic , primarily leading to acute kidney injury (AKI) and microangiopathic hemolytic anemia. Although free heme has been found to aggravate renal damage in hemolytic diseases, the relevance of the heme-degrading enzyme heme oxygenase-1 (HO-1, encoded by ) in HUS has not yet been investigated. We hypothesized that HO-1 also important in acute phase responses in damage and inflammation, contributes to renal pathogenesis in HUS.
View Article and Find Full Text PDFIL-7Rα on CD4 T cells is required for their survival and the pathogenesis of experimental autoimmune encephalomyelitis.
J Neuroinflammation
October 2024
Department of Neurology, Thomas Jefferson University, 900 Walnut Street, Suite 300, Philadelphia, PA, 19107, USA.
Article Synopsis
- The IL-7 receptor alpha (IL-7Rα) is crucial for the development and survival of CD4 T cells, but its role in maintaining these cells during autoimmune conditions like EAE (a model for multiple sclerosis) remains debated.
- Researchers created a double transgenic mouse model to investigate the effects of knocking out the IL-7Rα gene specifically in CD4 T cells and monitored the mice for EAE development.
- The study found that the absence of IL-7Rα led to a significant reduction in CD4 T cell numbers and prevented EAE development, indicating that IL-7Rα is essential for the function of CD4 T cells in autoimmune responses.
Targeting NGF but not VEGFR1 or BDNF signaling reduces endometriosis-associated pain in mice.
J Adv Res
August 2024
Vascular Biology Program, Department of Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States; Boston Center for Endometriosis, Boston Children's Hospital and Brigham and Women's Hospital, Boston, MA, United States. Electronic address:
Introduction: Endometriosis is a chronic inflammatory disease that affects ∼10 % of women. A significant fraction of patients experience limited or no efficacy with current therapies. Tissue adjacent to endometriosis lesions often exhibits increased neurite and vascular density, suggesting that disease pathology involves neurotrophic activity and angiogenesis.
View Article and Find Full Text PDFImprovement of Tamoxifen Induced Foveal Cavitation with Topical Dorzolamide Therapy.
Retin Cases Brief Rep
July 2024
Retinal Disorders and Ophthalmic Genetics Division, Stein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Purpose: To present a case of severe foveal cavitation and near complete macular hole secondary to tamoxifen toxicity that improved after tamoxifen cessation and topical dorzolamide therapy.
Methods: A 45-year-old female referred with bilateral tamoxifen maculopathy. Bilateral foveal cavitation, worse in the right eye (OD) with draping of the internal limiting membrane, was noted with baseline optical coherence tomography.
Mitochondrial DNA mutations attenuate Bleomycin-induced dermal fibrosis by inhibiting differentiation into myofibroblasts.
Matrix Biol
September 2024
Department of Dermatology and Venereology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, Germany. Electronic address:
Post-mitotic, non-proliferative dermal fibroblasts have crucial functions in maintenance and restoration of tissue homeostasis. They are involved in essential processes such as wound healing, pigmentation and hair growth, but also tumor development and aging-associated diseases. These processes are energetically highly demanding and error prone when mitochondrial damage occurs.
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