AI Article Synopsis
- The study examined how well self-assembled monolayers (SAMs) made from oligoproline, an antifouling peptide, interact with blood under conditions mimicking arterial flow.
- SAMs created from Pro6 and Pro9 showed a hydrophilic surface that effectively prevented adhesion of blood cells like leukocytes and platelets.
- Pro9-SAM specifically was found to fully inhibit platelet activation and acute thrombogenic responses, indicating its potential as a biocompatible material for medical applications.
Article Abstract
The blood compatibility of self-assembled monolayers (SAMs) of oligoproline, a nonionic antifouling peptide, was investigated using the cone-and-plate assay imitating arterial blood flow conditions. End-capped oligoprolines composed of 6 and 9 proline residues (Pro6 and Pro9) and a Cys residue were synthesized for preparing SAMs (Pro-SAMs) on Au-sputtered glass. The surface of Pro-SAMs indicated hydrophilic property with a smooth topology. The adsorption of blood components and the adhesion of blood cells, including leukocytes and platelets, were strongly suppressed on Pro-SAMs. Moreover, Pro9-SAM did not trigger the activation of platelets (, the conformational change of GPIIb/IIIa and P-selectin (CD62P) expression on platelets and the formation of aggregates). Our results demonstrate that Pro9-SAM completely inhibited acute thrombogenic responses and the activation of platelets under dynamic conditions.
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| http://dx.doi.org/10.1039/d2bm00885h | DOI Listing |
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