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Recent odor experience selectively modulates olfactory sensitivity across the glomerular output in the mouse olfactory bulb.
Chem Senses
December 2024
Department of Biological Science, Florida State University, Tallahassee, FL.
Although animals can reliably locate and recognize odorants embedded in complex environments, the neural circuits for accomplishing these tasks remain incompletely understood. Adaptation is likely to be important as it could allow neurons in a brain area to adjust to the broader sensory environment. Adaptive processes must be flexible enough to allow the brain to make dynamic adjustments, while maintaining sufficient stability so that organisms do not forget important olfactory associations.
View Article and Find Full Text PDFVapour phase deposition of phosphonate-containing alumina thin films using dimethyl vinylphosphonate as precursor.
Dalton Trans
January 2025
Department of Solid State Sciences, CoCooN research group, Ghent University, Krijgslaan 281 (S1), 9000 Gent, Belgium.
Phosphorous-containing materials are used in a wide array of fields, from energy conversion and storage to heterogeneous catalysis and biomaterials. Among these materials, organic-inorganic metal phosphonate solids and thin films present an interesting option, due to their remarkable thermal and chemical stability. Yet, the synthesis of phosphonate hybrids by vapour phase thin film deposition techniques remains largely unexplored.
View Article and Find Full Text PDFDeveloping Topics.
Alzheimers Dement
December 2024
University of California, San Francisco, San Francisco, CA, USA.
Background: An optimized 6 amino acid peptide (NLSYYT; herein YΦ) derived from the C-terminus of h19S proteasome activator Rpt5 has been shown to activate the 20S proteasome and promote tau degradation. Further analysis of this peptide has identified the highly conserved leucine in position 5 (P5) as a key part of the 20S activation mechanism to drive degradation of tau monomers in the absence of proteasome activator complexes.
Method: Recombinant peptides were used to identify key amino acids required for binding and activating the h20S proteasome.
Formulation Design, Optimization, and Evaluation of Solid Lipid Nanoparticles Loaded With an Antiviral Drug Tenofovir Using Box-Behnken Design for Boosting Oral Bioavailability.
Adv Pharmacol Pharm Sci
December 2024
Department of Pharmaceutics, SRM College of Pharmacy, SRMIST, Kattankulathur, Chennai, Tamil Nadu, India.
The current study aimed to improve the oral bioavailability of tenofovir (TNF), an antihuman immunodeficiency viral (HIV) drug, by integrating it into solid lipid nanoparticles (SLNs), an emerging lipid formulation. The suggested SLNs were generated utilizing the microemulsion process, using Compritol 888 ATO. A Box-Behnken experimental design was attempted to analyze the impact of critical quality attributes (CQAs), such as lipid and surfactant content and homogenization duration on response metrics such as particle size (PS) and percentage entrapment.
View Article and Find Full Text PDFAutomated gradation design of natural waste gravel soil stabilized by composite soil stabilizer based on a novel DNNSS-APDM-PFC model.
Waste Manag
January 2025
College of Civil Engineering, Nanjing Forestry University, Nanjing, 210037, China.
The utilization of natural waste gravel soil as base course material contributes to environmental protection and carbon emission reduction. The purpose of this research is to establish a new model for automated gradation design of the composite soil stabilizer-stabilized waste gravel soil (CSSWGS). A gradation range of CSSWGS has been proposed.
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