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Erratum - Effect of Danggui Buxue decoction on hypoxia-induced injury of retinal Müller cells .
Eur J Histochem
January 2025
Traditional Chinese Medicine Studio, The First Affiliated Hospital of Xiamen University; Integrated Traditional Chinese and Western Medicine Center, School of Medicine, Xiamen University, Xiamen.
This corrects the article published in European Journal of Histochemistry 2024;68:4140 doi: 10.4081/ejh.2024.
View Article and Find Full Text PDFEffect of Acute Hypoxia Exposure on the Availability of A Adenosine Receptors and Perfusion in the Human Brain.
J Nucl Med
January 2025
Institute of Neuroscience and Medicine, Molecular Organization of the Brain (INM-2), Forschungszentrum Jülich, Jülich, Germany;
In animal studies it has been observed that the inhibitory neuromodulator adenosine is released into the cerebral interstitial space during hypoxic challenges. Adenosine's actions on the A adenosine receptor (AAR) protect the brain from oxygen deprivation and overexertion through adjustments in cerebral blood flow, metabolism, and electric activity. Using 8-cyclopentyl-3-(3-[F]fluoropropyl)-1-propylxanthine ([F]CPFPX), a PET tracer for the AAR, we tested the hypothesis that hypoxia-induced adenosine release reduces AAR availability in the human brain.
View Article and Find Full Text PDFCorrection: Mitochondrial control of hypoxia-induced pathological retinal angiogenesis.
Angiogenesis
November 2024
Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, 3 Blackfan Circle, CLS 18, Boston, MA, 02115, USA.
The thienopyridine A-769662 and benzimidazole 991 inhibit human TASK-3 potassium channels in an AMPK-independent manner.
Biochem Pharmacol
December 2024
Centre for Discovery Brain Sciences, Hugh Robson Building, University of Edinburgh, Edinburgh EH8 9XD, UK. Electronic address:
Article Synopsis
- TASK-1/3 channels in carotid body type 1 cells are key for sensing low oxygen levels, affecting potassium currents and ultimately influencing breathing patterns.
- Recent studies questioned whether AMP-activated protein kinase (AMPK) directly inhibits TASK-3 channels in response to hypoxia, although a recognizable phosphorylation motif was found in human TASK-3.
- Experiments with various AMPK activators indicated that two compounds, A-769662 and 991, inhibit hTASK-3 currents, while establishing that AMPK does not regulate TASK-3 currents as initially proposed.
Erratum: Hypoxia induced exosomal circRNA promotes metastasis of Colorectal Cancer via targeting GEF-H1/RhoA axis: Erratum.
Theranostics
May 2024
Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, China.
[This corrects the article DOI: 10.7150/thno.44419.
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