Studying the natural wanderings of the living brain is extremely challenging. Bolt et al. describe a new framework to consider the brain’s intrinsic activity based on the geophysical concepts of standing and traveling waves.
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http://dx.doi.org/10.1038/s41593-022-01119-0 | DOI Listing |
J Med Biogr
January 2025
Houma, LA, USA.
The history of medicine as a component of the medical school curriculum has been a long-standing subject of debate and controversy. Ultimately, local factors may determine this experience and be aligned with or outside of the curriculum. The opportunity at Tulane University School of Medicine is long-standing and successful.
View Article and Find Full Text PDFNucl Med Commun
January 2025
Department of Oncology, University College London Hospitals NHS Foundation Trust and UCL Cancer Institute, University College London, London, UK.
Treatment with radioactive drugs (molecular radiotherapy, MRT) is an option for selected children with neuroblastoma and neuroendocrine cancers. As few hospitals are appropriately equipped and staffed to provide paediatric MRT, many families have to travel long distances from home for prolonged periods. To improve professional understanding of the challenges faced by children receiving these treatments and their parents, and to help them appreciate the difficulties faced by professionals in delivering complex treatments, a meeting bringing together parents, patients and professionals was held.
View Article and Find Full Text PDFAlzheimers Res Ther
January 2025
Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Gran Via Carles III 85 BIS, Barcelona, 08028, Spain.
Background: Alzheimer's disease (AD) stands as the leading cause of dementia worldwide, and projections estimate over 150 million patients by 2050. AD prevalence is notably higher in women, nearly twice that of men, with discernible sex differences in certain risk factors. To enhance our understanding of how sex influences the characteristics of AD patients and its potential impact on the disease trajectory, we conducted a comprehensive analysis of demographic, clinical, cognitive, and genetic data from a sizable and well-characterized cohort of AD dementia patients at a memory clinic in Barcelona, Spain.
View Article and Find Full Text PDFNat Med
January 2025
Department of Medicine-Medical Oncology, University of Colorado Cancer Center, Denver, CO, USA.
Effective targeting of somatic cancer mutations to enhance the efficacy of cancer immunotherapy requires an individualized approach. Autogene cevumeran is a uridine messenger RNA lipoplex-based individualized neoantigen-specific immunotherapy designed from tumor-specific somatic mutation data obtained from tumor tissue of each individual patient to stimulate T cell responses against up to 20 neoantigens. This ongoing phase 1 study evaluated autogene cevumeran as monotherapy (n = 30) and in combination with atezolizumab (n = 183) in pretreated patients with advanced solid tumors.
View Article and Find Full Text PDFLancet Oncol
January 2025
Department of Molecular Imaging and Therapy, Austin Health, Melbourne, VIC, Australia; Faculty of Medicine, University of Melbourne, Melbourne, VIC, Australia; Tumour Targeting Program, Olivia Newton-John Cancer Research Institute, Melbourne, VIC, Australia; School of Cancer Medicine, La Trobe University, Melbourne, VIC, Australia.
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