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Background: As a rare subtype of lung adenocarcinoma, the diagnosis of pulmonary enteric adenocarcinoma (PEAC) remains challenging due to overlapping morphologic spectrum with lung metastatic colorectal cancer (lmCRC). However, the molecular features of PEAC as a separate lung cancer entity are poorly understood.
Methods: We performed whole-exome sequencing and targeted bisulfite sequencing of 32 PEAC and 30 lmCRC to improve differential molecular characterization of the two diseases. We used machine learning methods to select key markers and developed a diagnostic classifier. In addition, we validated the classifier in the internal test cohort and an independently recruited external validation cohort with 17 PEAC and 7 lmCRC.
Findings: Our results showed that EGFR was the key driver mutation in PEAC but at a lower prevalence compared to typical lung adenocarcinomas, whereas ERBB2 and KRAS were more frequently observed in PEAC. By contrast, we observed significant enrichment of KRAS and APC mutations in lmCRC compared with PEAC. At the chromosome arm level, copy number variations in 13q, 14q, and 18p were the major chromosomal differences observed between PEAC and lmCRC. Furthermore, by comparing differentially methylated regions (DMRs), we established a neat DNA methylation-based classifier consisting of eight DMRs. This classifier correctly classified all samples in the training cohort and 95% of the samples in the internal test cohort. An external validation cohort of 24 cases recruited from multiple centers in China also reliably agreed with pathological diagnosis.
Interpretation: These results provide solid evidence of PEAC-specific genomic characteristics and demonstrate the potential utility of DNA methylation markers for auxiliary diagnosis of PEAC and lmCRC.
Funding: This work was supported by National key research and development project 2019YFC1315700, CAMS Key Laboratory of Translational Research on Lung Cancer (2018PT31035), and Beijing Natural Science Foundation (7222144).
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9334343 | PMC |
http://dx.doi.org/10.1016/j.ebiom.2022.104165 | DOI Listing |
J Phys Chem A
November 2024
School of Physical Science and Technology, Southwest Jiaotong University, Chengdu, Sichuan 610031, PR China.
To improve the comprehension of the combustion kinetics of 1-nitropropane (1-NP), the H-abstraction reactions from 1-NP by H and OH radicals are theoretically explored using the canonical variational transition-state theory combined with the multistructural torsional anharmonicity and small-curvature tunneling corrections (MS-CVT/SCT). The M08-HX/cc-pVTZ method is adopted for geometry optimizations and frequency calculations due to its effective performance in describing the current reaction systems with an average mean unsigned deviation of 0.95 kcal mol against the benchmark by the high-level DLPNO-CCSD(T)/CBS(T-Q) method.
View Article and Find Full Text PDFAnn Rheum Dis
November 2024
Department of Joint Surgery, Sun Yat-sen University First Affiliated Hospital, Guangzhou, Guangdong, China
Front Oncol
October 2024
Department of Nuclear Medicine, Jiangxi Provincial People's Hospital, the First Affiliated Hospital of Nanchang Medical College, Nanchang, China.
Pulmonary enteric adenocarcinoma (PEAC), an uncommon variant of lung cancer, presents significant diagnostic challenges due to its overlapping characteristics with colorectal adenocarcinomas. We present a case of a 55-year-old non-smoking female patient diagnosed with PEAC. The patient's initial symptoms included fever, cough, and sputum production, with air space consolidation on CT, leading to an initial diagnosis of pneumonia.
View Article and Find Full Text PDFAm J Med Open
December 2024
Department of Medicine, Division of Addiction Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Background: The introduction of direct-acting antivirals (DAA) has revolutionized hepatitis C virus (HCV) treatment but has not translated into an appreciable decline in HCV prevalence, which is estimated to be 2.4 million in the United States. Efforts are thought to be limited by the lack of experience among nonspecialist providers in managing HCV.
View Article and Find Full Text PDFPathol Res Pract
November 2024
Manipal Academy of Higher Education (MAHE), Manipal, Karnataka 576104, India; Institute of Bioinformatics, International Technology Park, Whitefield, Bangalore, Karnataka 560066, India. Electronic address:
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