Objective: This systematic review and meta-analysis aimed to confirm the role of Apparent Diffusion Coefficient (ADC) values in predicting the prognosis of PCNSL patients based on previous studies.
Methods: A systematic review with meta-analysis was conducted on related articles PubMed, Scopus, Sciencedirect, Cochrane, DOAJ, and Embase databases with last updated search on November 30, 2021. This systematic review and meta-analysis included a total of four studies.
Result: All studies that examined the association between pretherapeutic ADC values and OS and PFS discovered that lower ADC values were associated with significantly shorter OS and PFS. The analysis revealed that patients with low ADC values had a higher risk of death than those with high ADC values, with a pooled HR of 0.24 (95% CI: 0.10-0.56; Z = 3.26; p = 0.001). A meta-analysis of five data from three studies examining the association between ADC values and PFS was also conducted using a fixed-effects model due to the low heterogeneity values (I2 = 4%; p = 0.38). The data analysis revealed that the pooled HR was 0.25 (95% confidence interval [CI]: 0.14-0.44, Z = 4.18; p 0.00001).
Conclusion: Patients with low ADC values had significantly shorter overall survival and progression-free survival than those with high ADC values, so ADC values assessment prior to initial therapy administration can provide clinicians with valuable information about the prognosis of PCNSL.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9727351 | PMC |
| http://dx.doi.org/10.31557/APJCP.2022.23.7.2449 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Preclinical evaluation of zirconium-89 labeled anti-Trop2 antibody-drug conjugate (Trodelvy) for imaging in gastric cancer and triple-negative breast cancer.
Eur J Nucl Med Mol Imaging
January 2025
Departments of Radiology and Medical Physics, University of Wisconsin - Madison, Madison, WI, 53705, USA.
Purpose: Trophoblast cell-surface antigen 2 (Trop2) is overexpressed in various solid tumors and contributes to tumor progression, while its expression remains low in normal tissues. Trop2-targeting antibody-drug conjugate (ADC), sacituzumab govitecan-hziy (Trodelvy), has shown efficacy in targeting this antigen. Leveraging the enhanced specificity of ADCs, we conducted the first immunoPET imaging study of Trop2 expression in gastric cancer (GC) and triple-negative breast cancer (TNBC) models using Zr-labeled Trodelvy ([Zr]Zr-DFO-Trodelvy).
View Article and Find Full Text PDFImaging characteristics of brain microstructure and cerebral perfusion in Crohn's disease patients with anxiety: A prospective comparative study.
World J Gastroenterol
January 2025
Department of Radiology, The Affiliated Changzhou Second People's Hospital of Nanjing Medical University, Changzhou Medical Center, Changzhou 213000, Jiangsu Province, China.
Background: Anxiety is a common comorbidity in patients with Crohn's disease (CD). Data on the imaging characteristics of brain microstructure and cerebral perfusion in CD with anxiety are limited.
Aim: To compare the imaging characteristics of brain microstructure and cerebral perfusion among CD patients with or without anxiety and healthy individuals.
Diffusion tensor imaging features of white matter pathways in the brain after COVID-19 infection.
Radiologie (Heidelb)
January 2025
Department of Radiology, Bezmialem Vakıf University, Istanbul, Turkey.
Purpose: To determine whether there is a difference in apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values in white matter pathways in the subacute period after COVID-19 infection and to evaluate the correlation between diffusion tensor imaging (DTI) metrics and laboratory findings.
Material And Methods: The study included 64 healthy controls and 91 patients. Patients were classified as group 1 (all patients, n = 91), group 2 (outpatients, n = 58), or group 3 (inpatients, n = 33).
The expression of repulsive guidance molecule a in the rat brain and the diffusion tensor imaging evaluation for crossed cerebellar diaschisis.
Acta Radiol
January 2025
Radiology Department, Third Affiliated Hospital of Zhengzhou University, Zhengzhou City, PR China.
Background: Cerebral infarction is one of the most common diseases. Diffusion tensor imaging (DTI) has been used to evaluate for crossed cerebellar diaschisis (CCD) to observe the expression of repulsive guidance molecule a (RGMa), the axonal regeneration as well as the effect on neural functional recovery in the middle cerebral artery occlusion (MCAO) rat model.
Purpose: To certify the expression pattern of RGMa in cerebral infarction and the mechanism of CCD to provide a new target for clinical therapy.
The Apparent Diffusion Coefficient Color Map for Evaluating a Large Ischemic Core.
J Neuroradiol
January 2025
Department of Neurosurgery, University of Occupational and Environmental Health, Kitakyushu, Japan.
Introduction: Our previous work demonstrated that evaluating large ischemic cores using the apparent diffusion coefficient (ADC) could predict EVT outcomes, with the most frequent ADC (peak ADC) ≥520×10 mm/s associated with better clinical results. Since the degree of ADC reduction reflects the severity of ischemic stress, this study aimed to assess the utility of an ADC color map in visualizing this stress.
Patients And Methods: This retrospective cohort study included consecutive patients with a low Alberta Stroke Program Early Computed Tomography Score (ASPECTS) using diffusion-weighted imaging (DWI) who underwent successful EVT recanalization between April 2014 and March 2023.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!