AI Article Synopsis
- A DAST-mediated reaction converts cyclopropyl silyl ethers in nitriles into allylic amides, yielding moderately good results (up to 87%).
- Time course investigations utilizing ReactIR and O-isotopic labeling have indicated that this reaction follows a Ritter-type mechanism.
- The study highlights the effectiveness of this method for producing allylic amides through a specific chemical process.
Article Abstract
A diethylaminosulfur trifluoride (DAST)-mediated ring-opening reaction of cyclopropyl silyl ethers in nitriles produced allylic amides in moderate to good yields (up to 87%). Time course studies using ReactIR and O-isotopic labeling mechanistic studies suggested that the present reaction occurs a Ritter-type process, leading to the formation of allylic amides.
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| http://dx.doi.org/10.1039/d2ob00940d | DOI Listing |
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