AI Article Synopsis
- The 6-cysteine protein family is a key group of surface antigens involved in various stages of parasite development and plays a role in parasite transmission and evasion of the host's immune system.
- Many members share a common feature called the 6-cysteine domain, which is crucial for their function across different parasites in the Aconoidasida group.
- This review covers methods for producing these proteins, the development of monoclonal antibodies that can prevent parasite transmission, and insights gained from crystal structures that reveal the proteins' functional domains.
Article Abstract
The 6-cysteine protein family is one of the most abundant surface antigens that are expressed throughout the life cycle. Many members of the 6-cysteine family have critical roles in parasite development across the life cycle in parasite transmission, evasion of the host immune response and host cell invasion. The common feature of the family is the 6-cysteine domain, also referred to as s48/45 domain, which is conserved across Aconoidasida. This review summarizes the current approaches for recombinant expression for 6-cysteine proteins, monoclonal antibodies against 6-cysteine proteins that block transmission and the growing collection of crystal structures that provide insights into the functional domains of this protein family.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9309271 | PMC |
| http://dx.doi.org/10.3389/fcimb.2022.945924 | DOI Listing |
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