The circadian clock (CC) is a daily system that regulates the oscillations of physiological processes and can respond to the external environment in order to maintain internal homeostasis. For the functioning of the CC, the clock genes (CG) act in different metabolic pathways through the clock-controlled genes (CCG), providing cellular regulation. The CC's interruption can result in the development of different diseases, such as neurodegenerative and metabolic disorders, as well as cancer. Leukemias correspond to a group of malignancies of the blood and bone marrow that occur when alterations in normal cellular regulatory processes cause the uncontrolled proliferation of hematopoietic stem cells. This review aimed to associate a deregulated CC with the manifestation of leukemia, looking for possible pathways involving CG and their possible role as leukemic biomarkers.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9332415 | PMC |
| http://dx.doi.org/10.3390/ijms23158212 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
KaiC family ATPases in the nonheterocystous nitrogen-fixing cyanobacterium Leptolyngbya boryana.
Sci Rep
December 2024
Graduate School of Life Sciences, Ritsumeikan University, Kusatsu, Shiga, 525-8577, Japan.
A circadian clock is reconstituted in vitro by incubating three proteins, KaiA, KaiB, and KaiC from the non-nitrogen-fixing cyanobacterium Synechococcus elongatus PCC 7942 in the presence of ATP. Leptolyngbya boryana is a filamentous cyanobacterium that grows diazotrophically under microoxic conditions. Among the aforementioned proteins, KaiC is the main clock oscillator belonging to the RecA ATPase superfamily.
View Article and Find Full Text PDFCross-species regulatory network analysis identifies FOXO1 as a driver of ovarian follicular recruitment.
Sci Rep
December 2024
Departments of Animal and Food Sciences, Biological Sciences, Medical and Molecular Sciences, and Microbiology Graduate Program, University of Delaware, Newark, DE, USA.
The transcriptional regulation of gene expression in the latter stages of follicular development in laying hen ovarian follicles is not well understood. Although differentially expressed genes (DEGs) have been identified in pre-recruitment and pre-ovulatory stages, the master regulators driving these DEGs remain unknown. This study addresses this knowledge gap by utilizing Master Regulator Analysis (MRA) combined with the Algorithm for the Reconstruction of Accurate Cellular Networks (ARACNe) for the first time in laying hen research to identify master regulators that are controlling DEGs in pre-recruitment and pre-ovulatory phases.
View Article and Find Full Text PDFCircadian Influences on Brain Lipid Metabolism and Neurodegenerative Diseases.
Metabolites
December 2024
Department of Foundations of Medicine, New York University Grossman Long Island School of Medicine, Mineola, NY 11501, USA.
Circadian rhythms are intrinsic, 24 h cycles that regulate key physiological, mental, and behavioral processes, including sleep-wake cycles, hormone secretion, and metabolism. These rhythms are controlled by the brain's suprachiasmatic nucleus, which synchronizes with environmental signals, such as light and temperature, and consequently maintains alignment with the day-night cycle. Molecular feedback loops, driven by core circadian "clock genes", such as Clock, Bmal1, Per, and Cry, are essential for rhythmic gene expression; disruptions in these feedback loops are associated with various health issues.
View Article and Find Full Text PDFLight responses during early day phases of CIRCADIAN CLOCK ASSOCIATED 1 (CCA1) and PSEUDO-RESPONSE REGULATOR (PRR) homologous genes in the moss Physcomitrium patens.
Photochem Photobiol
December 2024
Graduate School of Informatics, Nagoya University, Nagoya, Japan.
Circadian clocks facilitate organisms' adaptation to the day-night environmental cycle. Some of the component genes of the clocks ("clock genes") respond directly to changes in ambient light, supposedly allowing the clocks to synchronize to and/or oscillate robustly in the environmental cycle. In the dicotyledonous model plant Arabidopsis thaliana, the clock genes CIRCADIAN CLOCK ASSOCIATED 1 (CCA1), LATE ELONGATED HYPOCOTYL (LHY) and PSEUDO-RESPONSE REGULATOR 9 (PRR9) show transient expression in response to the morning light.
View Article and Find Full Text PDFCircadian Regulation of the Rice Immune Response during Rice Blast Infection via Metabolic and Calcium Signaling.
J Agric Food Chem
December 2024
College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310032, China.
The circadian clock is crucial in plant immunity and metabolism, yet the coordinating mechanisms remain elusive. In the present study, transcriptome analysis of -infected rice leaves and rhythmic analysis showed reduced amplitudes of circadian and phytochrome genes, impacting immune response, metabolic pathways, and calcium signaling. The amplitudes of pattern-triggered immunity (PTI)-related genes declined, while the rhythmicity of effector-triggered immunity (ETI)-related genes disappeared.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!