The development of humor is complex and heterogeneous within and across neurotypical and neurodivergent groups. Some autistics develop differences (not deficits) in humor appreciation, whereas others report difficulties "getting the joke" and identify this as in need of support. This is important because humor appreciation and comprehension are linked to psychological well-being and social success. This article describes the therapeutic potential for teaching humor comprehension to autistic persons and the benefit of broader education efforts to forge an understanding of the value of "different senses of humor." The nature and development of humor comprehension in neurotypical development and autism are reviewed. Considerations for whether and how to teach humor comprehension are offered that maximize goodness-of-fit, prioritize autistic autonomy, and promote the sharing and appreciation of different kinds of "funny."
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http://dx.doi.org/10.1055/s-0042-1750814 | DOI Listing |
J Cell Mol Med
January 2025
Institute of Molecular Medicine, Huaqiao University, Quanzhou, China.
Recombinant adeno-associated virus (rAAV) has emerged as one of the best gene delivery vectors for human gene therapy in vivo. However, the clinical efficacy of rAAV gene therapy is often hindered by the host immune response against its transgene products. Endoplasmic reticulum aminopeptidase 1 (ERAP1) is specialised to process peptides presented by class I molecules of major histocompatibility complex.
View Article and Find Full Text PDFOpen Med (Wars)
January 2025
Department of Toxicological Chemistry, National Poison Control Center, Military Medical Academy, Belgrade, 11000, Serbia.
Introduction: Qualitative and quantitative testing of ethanol in samples is an important analytical procedure that provides accurate, precise, and reliable results. Given the complexity of the issue, obtaining a realistic picture of lifelong alcoholemia requires supporting blood ethanol findings with analyses of alternative samples, primarily vitreous humor (VH).
Objective: The objective of this study was to develop and validate a headspace gas chromatography with flame ionization detection (HS/GC-FID) method for determining ethanol concentration in VH.
Small
January 2025
College of Chemistry Chemical Engineering and Materials Science, Collaborative Innovation Center of Suzhou Nano Science and Technology, National United Engineering Laboratory of Functionalized Environmental Adsorption Materials, Soochow University, Suzhou, 215123, China.
Although the design of photocatalysts incorporating donor-acceptor units has garnered significant attention for its potential to enhance the efficiency of the photocatalysis process, the primary bottleneck lies in the challenge of generating long-lived charge separation states during exciton separation. Therefore, a novel Janus-nanomicelles photocatalyst is developed using carbazole (Cz) as the donor unit, perylene-3,4,9,10-tetracarboxydiimide (PDI) with long-excited state as the acceptor unit and polyethylene glycol (PEG) as the hydrophilic segment through ROMP polymerization. After optimizing the ratio, Cz-PDI-PEG rapidly adsorbs bisphenol A (BPA) within 10 s through π-π interaction, hydrogen-bonding interaction, and hydrophobic interaction between BPA and hydrophobic blocks when exposed to aqueous humor and efficiently photodegrades BPA (50 ppm) within 120 min for water purification purposes due to its long-lived charge separation state and achieving the highest reported efficiency so far.
View Article and Find Full Text PDFBiol Psychol
January 2025
Department of Educational Psychology and Counseling, National Taiwan Normal University, Taipei 106308, Taiwan; Institute for Research Excellence in Learning Sciences, National Taiwan Normal University, Taipei 106308, Taiwan; Chinese Language and Technology Center, National Taiwan Normal University, Taipei 106308, Taiwan; Social Emotional Education and Development Center, National Taiwan Normal University, Taipei 106308, Taiwan. Electronic address:
Research on how functional connectivity (FC) during resting-state relates to humor styles and sex is limited. This study aimed to address this knowledge gap by analyzing resting-state fMRI data from 56 healthy participants and measuring FC. In addition, participants completed the Humor Styles Questionnaire.
View Article and Find Full Text PDFPharmaceutics
November 2024
Guangdong Provincial Key Laboratory of Advanced Drug Delivery, Guangdong Provincial Engineering Center of Topical Precise Drug Delivery System, Guangdong Pharmaceutical University, No. 280 University Town Outer Ring East Road, Guangzhou 510006, China.
Background: Internal ocular diseases, such as macular edema, uveitis, and diabetic macular edema require precise delivery of therapeutic agents to specific regions within the eye. However, the eye's complex anatomical structure and physiological barriers present significant challenges to drug penetration and distribution. Traditional eye drops suffer from low bioavailability primarily due to rapid clearance mechanisms.
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