AI Article Synopsis
- Kawasaki disease (KD) is a serious childhood illness that can be treated with infliximab (IFX), but concerns exist about the timing of live vaccinations in relation to this therapy.
- A study examined 48 children diagnosed with KD shortly after live vaccinations or BCG, finding that none of the eight who received IFX had vaccine-related infections.
- The results suggest that the waiting period between live vaccinations and IFX treatment for KD might be shorter than currently recommended, indicating the need for further research to confirm safety.
Article Abstract
Background: Kawasaki disease (KD) is an acute and febrile systemic vasculitis that occurs during childhood. Infliximab (IFX) is a chimeric monoclonal antibody that binds to tumor necrosis factor-α. Although IFX therapy is a useful option for refractory KD, vaccine-associated infections may develop after therapy. In Japan, IFX therapy is recommended after a duration of at least 3 months after live vaccinations or at least 6 months after Bacillus Calmette-Guérin (BCG) in children with KD. However, the appropriate duration between live vaccinations and IFX therapy is unclear.
Methods: We investigated children who developed KD within 3 months after live vaccinations or within 6 months after BCG. Clinical characteristics, side effects of therapies and efficacy of live vaccinations were retrospectively investigated.
Results: Forty-eight patients developed KD within 3 months of live vaccinations or within 6 months after BCG. Eight patients underwent IFX therapy. There were no apparent vaccine-associated infections. The patients who underwent IFX acquired protective IgG antibody titers in the 5 of 6 live vaccines.
Conclusions: Safe and appropriate duration between live vaccinations and IFX therapy for KD patients could be shorter in the future, although more studies are warranted to establish the safe duration.
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| http://dx.doi.org/10.1097/INF.0000000000003611 | DOI Listing |
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