Modeling and inference are central to most areas of science and especially to evolving and complex systems. Critically, the information we have is often uncertain and insufficient, resulting in an underdetermined inference problem; multiple inferences, models, and theories are consistent with available information. Information theory (in particular, the maximum information entropy formalism) provides a way to deal with such complexity. It has been applied to numerous problems, within and across many disciplines, over the last few decades. In this perspective, we review the historical development of this procedure, provide an overview of the many applications of maximum entropy and its extensions to complex systems, and discuss in more detail some recent advances in constructing comprehensive theory based on this inference procedure. We also discuss efforts at the frontier of information-theoretic inference: application to complex dynamic systems with time-varying constraints, such as highly disturbed ecosystems or rapidly changing economies.
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http://dx.doi.org/10.1073/pnas.2119089119 | DOI Listing |
JAMA Netw Open
January 2025
Department of Surgery, University of Washington, Seattle.
Importance: Timely access to care is a key metric for health care systems and is particularly important in conditions that acutely worsen with delays in care, including surgical emergencies. However, the association between travel time to emergency care and risk for complex presentation is poorly understood.
Objective: To evaluate the impact of travel time on disease complexity at presentation among people with emergency general surgery conditions and to evaluate whether travel time was associated with clinical outcomes and measures of increased health resource utilization.
Soft Robot
January 2025
Department of Mechanical and Nuclear Engineering, Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates.
Soft robots and bioinspired systems have revolutionized robot design by incorporating flexibility and deformable materials inspired by nature's ingenious designs. Similar to many robotic applications, sensing and perception are paramount to enable soft robots to adeptly navigate the unpredictable real world, ensuring safe interactions with both humans and the environment. Despite recent progress, soft robot sensorization still faces significant challenges due to the virtual infinite degrees of freedom of the system and the need for efficient computational models capable of estimating valuable information from sensor data.
View Article and Find Full Text PDFInorg Chem
January 2025
Research School of Chemistry, Australian National University, Canberra, ACT 2601, Australia.
In this study, we apply TD-DFT and DFT calculations to explore the mechanistic details of O evolution in an artificial system that closely resembles Photosystem II (PSII). The reaction involves mononuclear Mn(III) complex [Mn(salpd)(OH)] and -benzoquinone under light-driven conditions. Our calculations reveal that the Schiff-base ligand salpd plays a crucial role in several key steps of the reaction, including the light-mediated oxidation of [Mn(salpd)(OH)] to [Mn(salpd)(OH)] by -benzoquinone, the subsequent oxidation of [Mn(salpd)(OH)] to the key Mn(V) intermediate [Mn(salpd)(O)], and the critical O-O bond formation step.
View Article and Find Full Text PDFFASEB J
January 2025
Department of Chemical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA.
Milk is a multifaceted biofluid that is essential for infant nutrition and development, yet its cellular and bioactive components, particularly maternal milk cells, remain understudied. Early research on milk cells indicated that they cross the infant's intestinal barrier and accumulate within systemic organs. However, due to the absence of modern analytical techniques, these studies were limited in scope and mechanistic analysis.
View Article and Find Full Text PDFHealth Promot Int
January 2025
Saw Swee Hock School of Public Health, National University of Singapore, 12 Science Drive 2, Singapore, 117549,Singapore.
This is a state-of-the-art review of historical developments, current approaches and recommended future directions in physical activity (PA) research, practice and policy. Since the early epidemiological studies in the 1950s, PA research has developed from within a biomedical paradigm. There is now a strong evidence base linking PA with positive health outcomes.
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