Demographers and other social scientists often study effect heterogeneity (defined here as differences in outcome-predictor associations across groups defined by the values of a third variable) to understand how inequalities evolve between groups or how groups differentially benefit from treatments. Yet answering the question "Is the effect larger in group A or group B?" is surprisingly difficult. In fact, the answer sometimes reverses across scales. For example, researchers might conclude that the effect of education on mortality is larger among women than among men if they quantify education's effect on an odds-ratio scale, but their conclusion might flip (to indicate a larger effect among men) if they instead quantify education's effect on a percentage-point scale. We illuminate this flipped-signs phenomenon in the context of nonlinear probability models, which were used in about one third of articles published in Demography in 2018-2019. Although methodologists are aware that flipped signs can occur, applied researchers have not integrated this insight into their work. We provide formal inequalities that researchers can use to easily determine if flipped signs are a problem in their own applications. We also share practical tips to help researchers handle flipped signs and, thus, generate clear and substantively correct descriptions of effect heterogeneity. Our findings advance researchers' ability to accurately characterize population variation.

Download full-text PDF

Source
http://dx.doi.org/10.1215/00703370-10109444DOI Listing

Publication Analysis

Top Keywords

flipped signs
12
larger group
8
nonlinear probability
8
probability models
8
men quantify
8
quantify education's
8
larger
4
group depends
4
depends understanding
4
understanding nonlinear
4

Similar Publications

ResViT FusionNet Model: An explainable AI-driven approach for automated grading of diabetic retinopathy in retinal images.

Comput Biol Med

January 2025

Department of Creative Technologies, Air University, Islamabad, 44000, Pakistan. Electronic address:

Background And Objective: Diabetic Retinopathy (DR) is a serious diabetes complication that can cause blindness if not diagnosed in its early stages. Manual diagnosis by ophthalmologists is labor-intensive and time-consuming, particularly in overburdened healthcare systems. This highlights the need for automated, accurate, and personalized machine learning approaches for early DR detection and treatment.

View Article and Find Full Text PDF

Objective: The objective of this research is to enhance pneumonia detection in chest X-rays by leveraging a novel hybrid deep learning model that combines Convolutional Neural Networks (CNNs) with modified Swin Transformer blocks. This study aims to significantly improve diagnostic accuracy, reduce misclassifications, and provide a robust, deployable solution for underdeveloped regions where access to conventional diagnostics and treatment is limited.

Methods: The study developed a hybrid model architecture integrating CNNs with modified Swin Transformer blocks to work seamlessly within the same model.

View Article and Find Full Text PDF

Spontaneous base flipping helps drive Nsp15's preferences in double stranded RNA substrates.

Nat Commun

January 2025

Molecular and Cellular Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, 111 T. W. Alexander Drive, Research Triangle Park, NC, 27709, USA.

Coronaviruses evade detection by the host immune system with the help of the endoribonuclease Nsp15, which regulates levels of viral double stranded RNA by cleaving 3' of uridine (U). While prior structural data shows that to cleave double stranded RNA, Nsp15's target U must be flipped out of the helix, it is not yet understood whether Nsp15 initiates flipping or captures spontaneously flipped bases. We address this gap by designing fluorinated double stranded RNA substrates that allow us to directly relate a U's sequence context to both its tendency to spontaneously flip and its susceptibility to cleavage by Nsp15.

View Article and Find Full Text PDF

In the era of the Internet of Things (IoT), the transmission of medical reports in the form of scan images for collaborative diagnosis is vital for any telemedicine network. In this context, ensuring secure transmission and communication is necessary to protect medical data to maintain privacy. To address such privacy concerns and secure medical images against cyberattacks, this research presents a robust hybrid encryption framework that integrates quantum, and classical cryptographic methods.

View Article and Find Full Text PDF

DEEP LEARNING-BASED FRAMEWORK TO DETERMINE THE DEGREE OF COVID-19 INFECTIONS FROM CHEST X-RAY.

Georgian Med News

October 2024

6Clinical Nurse Specialist, Heart Hospital, Hamad Medical Corporation, Doha, Qatar.

The corona virus disease-19 (COVID-19) epidemic, the whole globe is suffering from a medical condition catastrophe that is unprecedented in scale. As the coronavirus spreads, scientists are worried about offering or helping in the supply of remedies to preserve lives and end the epidemic. Artificial intelligence (AI), for example, has occurred altered to deal with the difficulties raised by pandemics.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!