AI Article Synopsis
- A study investigated the link between iodine-deficient parenteral nutrition (PN) and thyroid dysfunction (TD) needing L-thyroxine (TD-LT4) in very low birth weight (VLBW) infants using data from the Korean Neonatal Network registry.
- Among 5635 VLBW infants, 8.7% developed TD-LT4, with higher rates (10.2%) in those on PN for 4 weeks or more, indicating prolonged PN as a risk factor for TD-LT4.
- Despite this, other factors like being small for gestational age (SGA) and complications such as seizures and pulmonary hypertension posed a greater risk for TD-LT4 than prolonged iodine-deficient
Article Abstract
Background: To investigate the impact of nutritional iodine deficiency on thyroid dysfunction (TD) in very low birth weight (VLBW) infants, we analyzed the association between iodine-deficient parenteral nutrition (PN) and TD requiring L-thyroxine (TD-LT4). Methods: Data of VLBW infants were obtained from the Korean Neonatal Network registry. Factors including duration of PN were analyzed according to TD-LT4. Results: TD-LT4 occurred in 490 (8.7%) of 5635 infants, and more frequently occurred in infants requiring PN for ≥4 weeks (10.2%). PN ≥ 4 weeks was one of the risk factors for TD-LT4, with an odds ratio (OR) of 1.346, p = 0.002. However, multivariate analysis showed that TD-LT4 was more of a risk for infants that were small for gestational age (OR 2.987, p < 0.001) and for other neonatal morbidities such as seizures (OR 1.787, p = 0.002) and persistent pulmonary hypertension (OR 1.501, p = 0.039) than PN ≥ 4 weeks (OR 0.791, p = 0.080). Conclusions: Prolonged iodine-deficient PN might affect TD-LT4 in VLBW infants. However, the effect of nutritional iodine deficiency on TD-LT4 risk was less than that of SGA or severe neonatal morbidities in Korean VLBW infants.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9331788 | PMC |
| http://dx.doi.org/10.3390/nu14153043 | DOI Listing |
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