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Application of efgartigimod in Chinese patients with myasthenia gravis: a single-center real-world prospective study.
Ther Adv Neurol Disord
January 2025
Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Background: China has a large number of myasthenia gravis (MG) patients, creating an urgent need for rapid and tolerable treatment options. As the first-approved Fc receptor antagonist, efgartigimod has bright prospects for treating MG. However, real-world evidence on its application within the Chinese MG population are limited.
View Article and Find Full Text PDFCurrent immunotherapy for thymic epithelial tumors: a narrative review.
Mediastinum
October 2024
Department of General Thoracic Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.
Background And Objective: Thymic epithelial tumors (TETs) are the most common neoplasm of the prevascular mediastinal compartment and are characterized by their rarity and variable clinical presentation. The present study aimed to explore the current management of patients with TET with a special focus on immunotherapy for advanced disease.
Methods: Relevant studies published between 1981 and 2024 were searched in PubMed using search terms "Thymoma", "Thymic cancer", "Myasthenia gravis", "Radiation therapy", "Surgery", and "Immunotherapy".
Application of digital tools and artificial intelligence in the Myasthenia Gravis Core Examination.
Front Neurol
December 2024
Department of Neurology & Rehabilitation Medicine, School of Medicine & Health Sciences, George Washington University, Washington, DC, United States.
Background: Advances in video image analysis and artificial intelligence provide opportunities to transform how patients are evaluated. In this study, we assessed the ability to quantify Zoom video recordings of a standardized neurological examination- the Myasthenia Gravis Core Examination (MG-CE)-designed for telemedicine evaluations.
Methods: We used Zoom (Zoom Video Communications) videos of patients with myasthenia gravis (MG) who underwent the MG-CE.
Unilateral Ptosis in a 72-Year-Old Male: Early Diagnosis of Myasthenia Gravis Using the Ice Pack Test.
Cureus
November 2024
Internal Medicine, Centro Hospitalar Universitário de Santo António, Porto, PRT.
Ptosis, or eyelid drooping, can be an early indicator of various neurological and muscular disorders, underscoring the need for accurate diagnosis to ensure proper management. Myasthenia gravis (MG), a neuromuscular disorder, may initially present with isolated ocular symptoms, often resulting in diagnostic delays. This report details the case of a 72-year-old male who presented to the emergency department with a two-week history of progressive unilateral ptosis.
View Article and Find Full Text PDFCurrent and Future Roles of Chimeric Antigen Receptor T-Cell Therapy in Neurology: A Review.
JAMA Neurol
January 2025
Department of Neurology, Medical Faculty and University Hospital, Heinrich-Heine University of Düsseldorf, Düsseldorf, Germany.
Article Synopsis
- Advancements in molecular engineering have led to the development of CAR T-cell therapy, showing potential for treating various neurological disorders, including brain tumors and autoimmune conditions.
- Although initial human trials for treating glioblastoma have had limited success, animal studies show promise for other conditions like multiple sclerosis and neuromyelitis optica spectrum disorders.
- Innovative strategies using modified CAR T cells targeting autoreactive B cells are showing potential for treating autoimmune encephalitis, suggesting a hopeful future for CAR T-cell applications in neurology.
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