AI Article Synopsis
- Endodontic-related diseases are among the most costly health issues in developed countries, focusing on treating dental pulp disorders and their complications.
- Current treatment methods face challenges in effectively disinfecting complex root canal systems, with a success rate of only about 85%.
- Nanoparticles are proposed as a promising solution for enhancing drug delivery and therapeutic outcomes in endodontics, and this review covers their applications, effectiveness, and recent advancements, particularly in biodegradable nanoparticles for disinfection.
Article Abstract
Endodontic-related diseases constitute the fourth most expensive pathologies in industrialized countries. Specifically, endodontics is the part of dentistry focused on treating disorders of the dental pulp and its consequences. In order to treat these problems, especially endodontic infections, dental barriers and complex root canal anatomy should be overcome. This constitutes an unmet medical need since the rate of successful disinfection with the currently marketed drugs is around 85%. Therefore, nanoparticles constitute a suitable alternative in order to deliver active compounds effectively to the target site, increasing their therapeutic efficacy. Therefore, in the present review, an overview of dental anatomy and the barriers that should be overcome for effective disinfection will be summarized. In addition, the versatility of nanoparticles for drug delivery and their specific uses in dentistry are comprehensively discussed. Finally, the latest findings, potential applications and state of the art nanoparticles with special emphasis on biodegradable nanoparticles used for endodontic disinfection are also reviewed.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316632 | PMC |
| http://dx.doi.org/10.3390/pharmaceutics14071519 | DOI Listing |
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