In this Issue, I have collected ten research papers and four review articles trying to describe the technologies that have evolved in the past ten years for the development of micro and nano systems for drug carry, targeting and delivery [...].
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9315868 | PMC |
| http://dx.doi.org/10.3390/pharmaceutics14071440 | DOI Listing |
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Assessing the Efficacy of Pyrolysis-Gas Chromatography-Mass Spectrometry for Nanoplastic and Microplastic Analysis in Human Blood.
Environ Sci Technol
January 2025
Queensland Alliance for Environmental Health Sciences (QAEHS), The University of Queensland, 20 Cornwall Street, Woolloongabba, Queensland 4102, Australia.
Humans are constantly exposed to micro- and nanosized plastics (MNPs); however, there is still limited understanding of their fate within the body, partially due to limitations with current analytical techniques. The current study assessed the appropriateness of pyrolysis-gas chromatography-mass spectrometry (Py-GC-MS) analysis for the quantification of a range of polymers in human blood. An extraction protocol that reduced matrix interferences (false positives) of polyethylene (PE) and polyvinyl chloride (PVC) was developed and validated.
View Article and Find Full Text PDFIntegrated SegFlow, µSIA, and UPLC for Online Sialic Acid Quantitation of Glycoproteins Directly from Bioreactors.
Eng Life Sci
January 2025
Analytical Development & Analytical Attribute Science in Biologics Bristol Myers Squibb Devens Massachusetts USA.
This study emphasizes the critical importance of closely monitoring and controlling the sialic acid content in therapeutic glycoproteins, including EPO, interferon-γ, Orencia, Enbrel, and others, as the level of sialylation directly impacts their pharmacokinetics (PK), immunogenicity, potency, and overall clinical performance due to its influence on protein clearance via hepatic asialoglycoprotein receptors (ASGPR). The ASGPR recognizes and binds to glycoproteins exposed to terminal galactose or N-acetylgalactosamine residues, leading to receptor-mediated endocytosis. Recent studies have demonstrated that sialylation of O-linked glycan plays a role in protecting against macrophage galactose lectin (MGL)-mediated clearance.
View Article and Find Full Text PDFBioceramic Surface Topography Regulating Immune Osteogenesis.
BME Front
January 2025
State Key Laboratory of High-Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, P. R. China.
This study aims to clarify the effects of bioceramic interface cues on macrophages. Recently, there have been many researches exploring the effects of interface topography cues on macrophage polarization and cytokine secretion. However, the effects and underlying mechanisms of bioceramic interface cues on macrophages still need exploring.
View Article and Find Full Text PDFEnhanced bioaccumulation and toxicity of Fenpropathrin by polystyrene nano(micro)plastics in the model insect, silkworm (Bombyx mori).
J Nanobiotechnology
January 2025
Max Planck Partner Group, Institute of Sericulture and Apiculture, Faculty of Agriculture, Life and Environmental Sciences, Zhejiang University, Hangzhou, China.
Background: Nano(micro)plastics (NMPs) and agrochemicals are ubiquitous pollutants. The small size and physicochemical properties of NMPs make them potential carriers for pollutants, affecting their bioavailability and impact on living organisms. However, little is known about their interactions in terrestrial ecosystems.
View Article and Find Full Text PDFAnalytical protocol for measuring micro-molar quantities of sulfur volatile species in experimental high pressure and temperature fluids.
Commun Chem
January 2025
Dipartimento di Scienze Della Terra, Università Degli Studi di Milano, via Mangiagalli 34, I-20133, Milano, Italy.
Validating thermodynamic models is essential in experimental geosciences for exploring increasingly complex systems and developing analytical protocols. However, investigating solid-fluid equilibria in mm-sized experimental capsules poses several challenges, particularly in sulfur-bearing chemical systems. These include maintaining bulk fluid composition and performing quantitative analysis with extremely low amounts of synthesized fluid.
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