From the dried vines of Hemsl, five new polyoxypregnane glycosides, named obcordatas J-N (-), were obtained. Their structures were fully elucidated and characterized by HRESIMS and extensive spectroscopic data. In addition, all of the new compounds were screened for their antinephrolithiasis activity in vitro. The results showed that compounds - have prominent protective effects on calcium oxalate crystal-induced human kidney 2 (HK-2) cells, with EC values ranging from 6.72 to 14.00 μM, which is consistent with the application value of in folk medicine for kidney stones.
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| http://dx.doi.org/10.3390/molecules27144596 | DOI Listing |
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