Type III secretion systems (T3SSs) are molecular devices that are essential for the communication of many Gram-negative bacteria with their eukaryotic hosts [...].
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http://dx.doi.org/10.3390/microorganisms10071461 | DOI Listing |
Objective: Scleroderma-associated autoantibodies (SSc-Abs) are specific in participants (pts) with systemic sclerosis and are associated with organ involvement. Our objective was to assess the influence of baseline SSc-Abs on the trajectories of the clinical outcome assessments (COAs) in a phase III randomized controlled trial.
Methods: We used data on both the groups who received placebo (Pbo) and tocilizumab from the focuSSced trial.
Zool Res
January 2025
Fisheries College, Jimei University, Xiamen, Fujian 361021, China. E-mail:
Small RNAs (sRNAs) are a class of molecules capable of perceiving environmental changes and exerting post-transcriptional regulation over target gene expression, thereby influencing bacterial virulence and host immune responses. is a pathogenic bacterium that poses a significant threat to aquatic animal health. However, the regulatory mechanisms of sRNAs in .
View Article and Find Full Text PDFPharm Stat
January 2025
Division of Biostatistics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Clinical trials (CTs) often suffer from small sample sizes due to limited budgets and patient enrollment challenges. Using historical data for the CT data analysis may boost statistical power and reduce the required sample size. Existing methods on borrowing information from historical data with right-censored outcomes did not consider matching between historical data and CT data to reduce the heterogeneity.
View Article and Find Full Text PDFSurg Pract Sci
September 2023
Department of Surgery, Bassett Medical Center, Cooperstown, NY, USA.
Background: Rural hospitals cover 20% of the United States (US) population with only 10% of physician coverage. A mismatch exists in pediatric trauma resources as there is overwhelming trauma support concentrated in urban trauma centers. Well-established guidelines for evaluating pediatric trauma patients in resource-limited environments are currently not available.
View Article and Find Full Text PDFSurg Pract Sci
September 2023
Al Faisal University, College of Medicine, Riyadh, Saudi Arabia.
Introduction: The current gold standard of treatment aortoiliac aneurysms are through endovascular aneurysm repairs which can result in occluding the internal iliac artery. An alternative that preserves internal iliac artery blood flow is the sandwich technique. This is when two covered stents of the internal and external iliac arteries are placed inside the main limb of common iliac artery stent.
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