AI Article Synopsis
- - The ocular microbiome plays a crucial role in maintaining eye health, and its disruption can affect eye functionality.
- - A study collected conjunctival swabs from newborns before and after antibiotic treatment to analyze changes in microbiota composition through 16S rRNA sequencing.
- - Results showed that gentamicin antibiotic treatment significantly reduced certain bacterial groups while increasing others, highlighting the need to understand these changes to prevent potential negative effects on eye health.
Article Abstract
Unlabelled: The ocular microbiome is of fundamental importance for immune eye homeostasis, and its alteration would lead to an impairment of ocular functionality. Little evidence is reported on the composition of the ocular microbiota of term infants and on the impact of antibiotic prophylaxis.
Methods: A total of 20 conjunctival swabs were collected from newborns at birth and after antibiotic treatment. Samples were subjected to 16S rRNA sequencing via system MiSeq Illumina. The data were processed with the MicrobAT software and statistical analysis were performed using two-way ANOVA.
Results: Antibiotic prophylaxis with gentamicin altered the composition of the microbiota. In detail, a 1.5- and 2.01-fold reduction was recorded for () and (), respectively, whereas an increase in spp. of 6.5 times occurred after antibiotic exposure.
Conclusions: Antibiotic prophylaxis altered the ocular microbiota whose understanding could avoid adverse effects on eye health.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320102 | PMC |
| http://dx.doi.org/10.3390/microorganisms10071390 | DOI Listing |
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