AI Article Synopsis
- Hypertensive disorders affect over 10% of twin pregnancies, prompting a study on neutrophil gelatinase-associated lipocalin (NGAL) levels in these women.
- The research involved 242 twin pregnancies at the Medical University of Vienna, where serum NGAL was measured multiple times during pregnancy and postpartum.
- Results indicated that NGAL levels significantly increased throughout pregnancy and postpartum, and notably, higher NGAL values were found in women who experienced pregnancy hypertension or preeclampsia compared to those with normal blood pressure.
Article Abstract
Hypertensive disorders complicate more than 10% of twin pregnancies. Several studies showed increased neutrophil gelatinase-associated lipocalin (NGAL) values in women with singleton pregnancies and preeclampsia. This study aimed to assess NGAL values in twin pregnancies complicated by hypertensive disorders. We conducted a study of 242 consecutive twin pregnancies at the Medical University of Vienna. Serum NGAL was evaluated twice during pregnancy and once in the postpartum period. Furthermore, serum NGAL values were compared between women who developed hypertensive disorders and those who had normal blood pressure. In all twin pregnancies, mean NGAL values increased significantly from the first to the second visit (p = 0.004) and, further, after delivery (p < 0.001). NGAL was significantly higher in pregnancies that developed pregnancy hypertension or preeclampsia when compared to the control group at the first visit (109.2 ± 48.9 ng/mL vs. 91.9 ± 29.4 ng/mL, p = 0.04, respectively). The predictive power of first visit NGAL values for development of pregnancy hypertension or preeclampsia was evaluated. When using a cut-off value of 115 ng/mL, we obtained a sensitivity of 45% with a specificity of 77%. We conclude that women with twin pregnancies who develop hypertensive disorders of pregnancy showed increased NGAL values at 11−16 weeks.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9318711 | PMC |
| http://dx.doi.org/10.3390/jcm11144163 | DOI Listing |
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