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Cross-Protection Induced by Virus-like Particles Derived from the Influenza B Virus. | LitMetric

Cross-Protection Induced by Virus-like Particles Derived from the Influenza B Virus.

Biomedicines

Department of Medical Zoology, School of Medicine, Kyung Hee University, Seoul 02447, Korea.

Published: July 2022

AI Article Synopsis

  • * Researchers developed virus-like particle (VLP) vaccines that express key antigens from two different influenza B virus lineages, specifically targeting hemagglutinin and neuraminidase.
  • * Testing showed these VLP vaccines were effective in mice, reducing viral loads and ensuring survival after infection with a mismatched virus, linked to strong immune responses.

Article Abstract

The mismatch between the circulating influenza B virus (IBV) and the vaccine strain contributes to the rapid emergence of IBV infection cases throughout the globe, which necessitates the development of effective vaccines conferring broad protection. Here, we generated influenza B virus-like particle (VLP) vaccines expressing hemagglutinin, neuraminidase, or both antigens derived from the influenza B virus (B/Washington/02/2019 (B/Victoria lineage)-like virus, B/Phuket/3073/2013 (B/Yamagata lineage)-like virus. We found that irrespective of the derived antigen lineage, immunizing mice with the IBV VLPs significantly reduced lung viral loads, minimized bodyweight loss, and ensured 100% survival upon Victoria lineage virus B/Colorado/06/2017 challenge infection. These results were closely correlated with the vaccine-induced antibody responses and HI titer in sera, IgG, IgA antibody responses, CD4+ and CD8+ T cell responses, germinal center B cell responses, and inflammatory cytokine responses in the lungs. We conclude that hemagglutinin, neuraminidase, or both antigen-expressing VLPs derived from these influenza B viruses that were circulating during the 2020/21 season provide cross-protections against mismatched Victoria lineage virus (B/Colorado/06/2017) challenge infections.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313027PMC
http://dx.doi.org/10.3390/biomedicines10071618DOI Listing

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