AI Article Synopsis
- Connexins and pannexins are transmembrane proteins that facilitate the transport of molecules and electrical signals between the external environment and the cell cytoplasm, with connexins also connecting adjacent cells for intercellular transport.
- The analysis focuses on understanding the similarities and differences between connexin and pannexin, specifically examining their hydrophobicity distribution.
- A mathematical model called the FOD-M (fuzzy oil drop model) is utilized to compare the external force fields affecting these proteins, highlighting how their environments differ from those of globular proteins in polar conditions.
Article Abstract
Connexins and pannexins are the transmembrane proteins of highly distinguished biological activity in the form of transport of molecules and electrical signals. Their common role is to connect the external environment with the cytoplasm of the cell, while connexin is also able to link two cells together allowing the transport from one to another. The analysis presented here aims to identify the similarities and differences between connexin and pannexin. As a comparative criterion, the hydrophobicity distribution in the structure of the discussed proteins was used. The comparative analysis is carried out with the use of a mathematical model, the FOD-M model (fuzzy oil drop model in its Modified version) expressing the specificity of the membrane's external field, which in the case of the discussed proteins is significantly different from the external field for globular proteins in the polar environment of water. The characteristics of the external force field influence the structure of protein allowing the activity in a different environment.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313468 | PMC |
| http://dx.doi.org/10.3390/biomedicines10071504 | DOI Listing |
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