AI Article Synopsis
- - Bone metastases are common in breast cancer, leading to abnormal blood vessel growth and bone damage, prompting researchers to test anti-angiogenic drugs (AAD) as a treatment strategy.
- - This study aimed to investigate how AAD affects the growth of blood vessels in bone during breast cancer metastasis by using advanced imaging techniques on mice treated with different combinations of AAD.
- - Results showed that early AAD treatment improved bone volume but later reduced the thickness of blood vessels, indicating it initially protects against bone loss but eventually alters bone blood vessel structure.
Article Abstract
Bone metastases are frequent complications of breast cancer, facilitating the development of anarchic vascularization and induce bone destruction. Therefore, anti-angiogenic drugs (AAD) have been tested as a therapeutic strategy for the treatment of breast cancer bone metastasis. However, the kinetics of skeletal vascularization in response to tumor invasion under AAD is still partially understood. Therefore, the aim of this study was to explore the effect of AAD on experimental bone metastasis by analyzing the three-dimensional (3D) bone vasculature during metastatic formation and progression. Seventy-three eight-week-old female mice were treated with AAD (bevacizumab, vatalanib, or a combination of both drugs) or the vehicle (placebo) one day after injection with breast cancer cells. Mice were sacrificed eight or 22 days after tumor cell inoculation (time points T1 and T2, respectively). Synchrotron radiation microcomputed tomography (SR-μCT) was used to image bone and blood vessels with a contrast agent. Hence, 3D-bone and vascular networks were simultaneously visualized and quantitatively analyzed. At T1, the trabecular bone volume fraction was significantly increased (p < 0.05) in the combined AAD-treatment group, compared to the placebo- and single AAD-treatment groups. At T2, only the bone vasculature was reduced in the combined AAD-treatment group (p < 0.05), as judged by measurement of the blood vessel thickness. Our data suggest that, at the early stage, combined AAD treatment dampens tumor-induced bone resorption with no detectable effects on bone vessel organization while, at a later stage, it affects the structure of bone microvascularization.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9321934 | PMC |
| http://dx.doi.org/10.3390/cancers14143443 | DOI Listing |
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