Mass concentration is a commonly used but insufficient metric to evaluate the particulate matter (PM) exposure hazard. Recent studies have declared that small particles have more serious impacts on human health than big particles given the same mass concentration. However, state-of-the-art PM sensors cannot provide explicit information of the particle size for further analysis. In this work, we adopt Sauter mean diameter (SMD) as a key metric to reflect the particle size besides the mass concentration. To measure SMD, an effective optical sensing method and a proof-of-concept prototype sensor are proposed by using dual wavelengths technology. In the proposed method, a non-linear conversion model is developed to improve the SMD measurement accuracy for aerosol samples of different particle size distributions and reflective indices based on multiple scattering channels. In the experiment of Di-Ethyl-Hexyl-Sebacate (DEHS) aerosols, the outputs of our prototype sensor demonstrated a good agreement with existing laboratory reference instruments with maximum SMD measurement error down to 7.04%. Furthermore, the simplicity, feasibility and low-cost features of this new method present great potential for distributed PM monitoring, to support sophisticated human exposure hazard assessment.
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http://dx.doi.org/10.3390/bios12070436 | DOI Listing |
J Environ Manage
January 2025
Savannah River Ecology Laboratory, University of Georgia, Aiken, SC 29802, USA. Electronic address:
The primary approach to assessing monitored natural attenuation (MNA) is currently based on a conceptual model utilizing the total contaminant concentrations, assuming a single aqueous species. However, many contaminants, such as metals and radionuclide - including iodine, can exist in multiple species that behave chemically differently in the environment and can exist simultaneously. For example, radioiodine often occurs concurrently as three major aqueous species: iodide (I), iodate (IO), and organo-I, which undergo distinct attenuation pathways and exhibit markedly different mobility and geochemical behavior.
View Article and Find Full Text PDFBiol Trace Elem Res
January 2025
Department of Geriatrics, The Second Affiliated Hospital, Nanjing Medical University, Nanjing, 210011, China.
Several studies have reported associations between specific heavy metals and essential trace elements and acute myocardial infarction (AMI). However, there is limited understanding of the relationships between trace elements and AMI in real-life co-exposure scenarios, where multiple elements may interact simultaneously. This cross-sectional study measured serum levels of 56 trace elements using inductively coupled plasma mass spectrometry.
View Article and Find Full Text PDFJ Proteome Res
January 2025
Segal Cancer Proteomics Centre, Lady Davis Institute for Medical Research, Jewish General Hospital and McGill University, Montreal, Quebec H3T 1E2, Canada.
The National Cancer Institute's Clinical Proteomics Tumor Analysis Consortium (CPTAC) was established to address the need for improved design, standardization, and validation of proteomics assays to enable better translation of biomarkers from the analytical lab to the clinic. Here, we applied CPTAC guidelines to characterize quantitative mass spectrometry (MS) assays in a new multiple reaction monitoring (MRM) proteomics panel. The panel of 50 proteins was developed in response to a previous study that identified a proteomic profile of altered translational control associated with response to a new cancer drug.
View Article and Find Full Text PDFEndocr Connect
January 2025
P Kamenický, Centre de Référence des Maladies Rares de l'Hypophyse, Le Kremlin-Bicêtre, 94275, France.
Background: Arterial hypertension and left ventricular hypertrophy and remodeling are independent cardiovascular risk factors in patients with Cushing's syndrome. Changes in the renin-angiotensin system and in the mineralocorticoid axis activity could be involved as potential mechanisms in their pathogenesis, in addition to cortisol excess.
Methods: In this ancillary study of our previous study prospectively investigating patients with ACTH-dependent Cushing's syndrome by cardiac magnetic resonance imaging (NCT02202902), 11 patients without any interfering medication were cross-sectionally compared to 20 control subjects matched for age, sex and body mass index.
Epilepsia
January 2025
Equine and Companion Animal Nutrition, Department of Morphology, Imaging, Orthopedics, Rehabilitation, and Nutrition, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium.
Objective: Idiopathic epilepsy (IE) is the most common chronic neurological disease in dogs and an established natural animal model for human epilepsy types with genetic and unknown etiology. However, the metabolic pathways underlying IE remain largely unknown.
Methods: Plasma samples of healthy dogs (n = 39) and dogs with IE (n = 49) were metabolically profiled (n = 121 known target metabolites) and fingerprinted (n = 1825 untargeted features) using liquid chromatography coupled to mass spectrometry.
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