AI Article Synopsis
- Pleural effusions (PEs) can result from various diseases, and identifying the underlying cause is crucial for treatment and prognosis.
- This study investigated the relationship between nitrite/nitrate levels in PEs and conditions like inflammation and infection, measuring samples from 143 patients.
- Results indicated that higher nitrite concentrations and nitrite/nitrate ratios were present in exudates compared to transudates, suggesting that the nitrite/nitrate ratio could serve as a useful diagnostic biomarker for differentiating infectious PEs from other types.
Article Abstract
Pleural effusions (PEs) are common in clinical practice and can be due to many different underlying diseases such as cancer, congestive heart failure, or pneumonia. An accurate differential diagnostic categorization is essential, as the treatment and prognosis of PEs largely depend on its cause. In this study, we tested the hypothesis that nitrite and nitrate concentrations in PEs are associated with the inflammation and infection conditions. We therefore measured the nitrite and nitrate levels in 143 PE samples using a sensitive liquid chromatography-tandem mass spectrometry method and investigated their diagnostic potential in differentiating PEs. The results showed that nitrite concentrations and nitrite/nitrate ratios were higher in exudates than in transudates (NO: 2.12 vs. 1.49 μM; NO/NO: 23.3 vs. 14.0). Both the nitrite concentrations and the nitrite/nitrate ratios were positively correlated with the three Light's criteria. Moreover, the receiver operating characteristic curve analysis revealed that the nitrite/nitrate ratio with an area under the curve of 0.71 could be a potential diagnostic biomarker in separating infectious PEs (IPEs) from other types of PEs. Taken together, the nitrite/nitrate ratio not only reflected the statuses of inflammation, but also the nitrate reduction by pathogenic bacteria infection in the pleural cavity. The nitrite/nitrate ratio could be a better biomarker in the differential diagnosis of PEs than the nitrite concentration alone.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9312090 | PMC |
| http://dx.doi.org/10.3390/antiox11071327 | DOI Listing |
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