Chemical Characterization of Taif Rose () Methanolic Extract and Its Physiological Effect on Liver Functions, Blood Indices, Antioxidant Capacity, and Heart Vitality against Cadmium Chloride Toxicity.

Exposure to cadmium chloride (CdCl) causes an imbalance in the oxidant status of the body by triggering the release of reactive oxygen species (ROS). This study investigated the effect of () extract on oxidative stress, hepatotoxicity, and the injured cardiac tissue of male rats exposed to CdCl. Forty male Wistar albino rats were divided into four groups: the vehicle control (1 mg/kg normal saline), the CdCl-treated group (5 mg/kg), the extract group (100 mg Kg), and the combination of CdCl and extract group. Male rats exposed to CdCl showed multiple significant histopathological changes in the liver and heart, including inflammatory cell infiltration and degenerative alterations. Successive exposure to CdCl elevated the levels of hepatic and cardiac reactive oxygen species (ROS), malondialdehyde (MDA), tumour necrosis factor-alpha) (TNF-α) and interleukin -6 (IL-6) and decreased antioxidant defences. The extracts significantly increased the levels of glutathione, superoxide dismutase (SOD), and catalase (CAT), whereas it dramatically decreased the levels of lipid peroxidation (LPO), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and the mRNA of TNF-α and IL-6. administration prevented liver and heart injury; suppressed excessive ROS generation, LPO, and inflammatory responses; and enhanced antioxidant defences. In addition, upregulated the mRNA of TNF-α and IL-6 in CdCl-administered male rats. In conclusion, modulated the oxidative stress and inflammation induced by CdCl. The hepatic and cardiac tissue damage and histopathological alterations resulting from the CdCl-induced oxidative stress were counteracted by the administration of extracts. enhanced antioxidant defence enzymes in male rats.