Regression of calcinosis cutis after inkless tattoo in a patient with dermatomyositis: therapeutic potential of microneedling.

Osteoporos Int

Division of Endocrinology, Gerontology and Metabolism, Stanford University School of Medicine, 300 Pasteur DrM/C 5103, Palo Alto, CA, 94305, USA.

Published: November 2022

Calcinosis cutis is defined as abnormal deposition of calcium salts in the skin and subcutaneous tissues. Dystrophic calcification, the most common form of calcinosis cutis, is associated with autoimmune connective tissue diseases. This condition is associated with severe pain and can affect the patient's quality of life and lead to long-term disability. Treatment is often challenging, and there is a very limited evidence base for potential treatments of calcinosis cutis associated with systemic sclerosis and dermatomyositis. Inkless tattoo is very similar to microneedling, a minimally invasive procedure stimulating the wound-healing cascade contributing to elastin and collagen formation as well as neovascularization. This technique has not been reported as a potential therapeutic option for calcinosis cutis. Here, we present a patient with calcinosis cutis in the setting of dermatomyositis that responded dramatically to inkless tattoo application. Our results support the need for future studies of microneedling in patients with this disorder.

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00198-022-06501-zDOI Listing

Publication Analysis

Top Keywords

calcinosis cutis
24
inkless tattoo
12
cutis associated
8
cutis
6
calcinosis
5
regression calcinosis
4
cutis inkless
4
tattoo patient
4
patient dermatomyositis
4
dermatomyositis therapeutic
4

Similar Publications

Hyperphosphatemic familial tumoral calcinosis (HFTC) is a rare, autosomal recessive condition characterized by fibroblast growth factor 23 signaling pathway dysregulation, hyperphosphatemia and ectopic calcifications (which manifest as joint motion limitations), inflammatory bony pain, and disability. Given the rarity and multiorgan involvement of HFTC, a multidisciplinary approach including Dermatology, Ophthalmology, Dentistry, Nephrology, Endocrinology, Rheumatology, and Genetics is necessary for diagnosis and treatment. We present a multidisciplinary diagnostic and treatment approach for a patient with HFTC due to a gene mutation with unique imaging highlighting the extent of calcinosis seen in HFTC.

View Article and Find Full Text PDF

Scrotal calcinosis is an infrequent benign pathological condition characterised by the presence of multiple calcified nodules on the skin of the scrotum. Despite the formulation of several theories, the precise pathogenesis of this condition remains a subject of controversy within the scientific community. The predominant concern associated with scrotal calcinosis is of an aesthetic nature, and histological examination serves as the definitive method for confirmation of the diagnosis.

View Article and Find Full Text PDF

A Clinicopathological Study of Scrotal Calcinosis and Literature Review.

Int J Surg Pathol

November 2024

Department of Pathology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.

Article Synopsis
  • The study examined 14 adult men with scrotal calcinosis to understand its clinicopathological features and potential causes, finding that it typically appears as hard nodules on the scrotum.
  • The analysis included comparisons with 81 cases of extrascrotal calcinosis and a large group of patients with epidermoid cysts, suggesting that scrotal calcinosis may arise from epidermoid cysts rather than being idiopathic.
  • The disease is characterized by calcium deposits in the skin and is generally asymptomatic, with surgical excision being an effective treatment.
View Article and Find Full Text PDF

Treatment of Calcinosis in Dermatomyositis-Case Report and Review.

J Clin Med

October 2024

Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, Collegium Medicum, University of Warmia and Mazury, Al. Wojska Polskiego 30, 10-229 Olsztyn, Poland.

Calcinosis cutis (CC) is a condition that may develop in the course of several autoimmune connective tissue diseases (ACTDs). Among these, the conditions most frequently associated with CC are systemic sclerosis (SSc) and dermatomyositis (DM). Despite both the prevalence and diversity of available treatment options, therapeutic recommendations remain not fully established due to a limited number of studies and lack of unambiguous evidence regarding their effectiveness.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!