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Seizing the opportunity to therapeutically address neuronal hyperexcitability in Alzheimer's disease.
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Department of Pharmaceutics, University of Washington, Seattle, WA, USA.
Seizures in people with Alzheimer's disease are increasingly recognized to worsen disease burden and accelerate functional decline. Harnessing established antiseizure medicine discovery strategies in rodents with Alzheimer's disease associated risk genes represents a novel way to uncover disease modifying treatments that may benefit these Alzheimer's disease patients. This commentary discusses the recent evaluation by Dejakaisaya and colleagues to assess the antiseizure and disease-modifying potential of the repurposed cephalosporin antibiotic, ceftriaxone, in the Tg2576 mouse model.
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The Latarjet procedure is a successful treatment for anterior shoulder instability with less than 5% having redislocations - revision surgery and prior surgery having been shown to be significant risk factors for recurrence. Approximately 90% of athletes return to play after Latarjet, comparable to arthroscopic Bankart repair. Patients may be physically unable to return to play, which may be due to persistent pain, apprehension, or weakness.
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