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Evaluation of an integrated variable flip angle protocol to estimate coil B for hyperpolarized MRI.
Magn Reson Med
November 2024
Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, UK.
Purpose: The purpose of this work is to validate a simple and versatile integrated variable flip angle (VFA) method for mapping B in hyperpolarized MRI, which can be used to correct signal variations due to coil inhomogeneity.
Theory And Methods: Simulations were run to assess performance of the VFA B mapping method compared to the currently used constant flip angle (CFA) approach. Simulation results were used to inform the design of VFA sequences, validated in four volunteers for hyperpolarized xenon-129 imaging of the lungs and another four volunteers for hyperpolarized carbon-13 imaging of the human brain.
Direct imaging of pulmonary gas exchange with hyperpolarized xenon MRI.
Innovation (Camb)
November 2024
State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan 430071, China.
Regional variations in hyperpolarized 129Xe lung MRI: Insights from CSI-CSSR and CSSR in healthy and irradiated rat models.
Magn Reson Med
November 2024
Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Purpose: To compare pulmonary function metrics obtained with hyperpolarized xenon-129 (HXe) MRS, using chemical shift saturation recovery (CSSR) and CSI-CSSR, in healthy rats and a rat model of radiation-induced lung injury.
Methods: HXe-MR data were acquired in two healthy rats and one rat with radiation-induced lung injury using whole-lung spectroscopy and CSI-CSSR techniques. The CSI-CSSR acquisitions were performed with both fixed TE and variable TE.
Cystic Fibrosis or asthma? Discerning dyspnea with hyperpolarizaed xenon gas magnetic resonance imaging.
Magn Reson Imaging
January 2025
Department of Internal Medicine, University of Missouri, 1 Hospital Drive, Columbia, MO 65212, USA. Electronic address:
Hyperpolarized Xenon MRI (HPG MRI) has been studied for its potential use in assessing lung function in patients with cystic fibrosis (CF) and in patients with asthma. We present a case of a man with overlapping cystic fibrosis and allergic asthma with severe obstructive lung disease in which spirometry and computed topography (CT) imaging was unable to determine the primary cause for his uncontrolled symptoms. HPG MRI was used to guide a tissue biopsy and determine the primary driver to be allergic asthma.
View Article and Find Full Text PDFHyperpolarized 129Xe Lung MRI and Spectroscopy in Mechanically Ventilated Mice.
J Vis Exp
October 2024
Center for Pulmonary Imaging Research, Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center; Department of Biomedical Engineering, University of Cincinnati; Imaging Research Center, Department of Radiology, Cincinnati Children's Hospital Medical Center; Department of Pediatrics, University of Cincinnati; Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center;
Article Synopsis
- Hyperpolarized xenon-129 (Xe) is a specialized MRI contrast agent that helps measure various aspects of lung function, making it useful for diagnosing and tracking lung diseases in humans.
- It is approved for clinical use in places like the U.S. and U.K. and offers noninvasive ways to study lung health in preclinical research settings, particularly with mice, which are commonly used in genetic studies.
- The text outlines practical procedures and checklists for effectively using Xe MRI in animal studies, focusing on ensuring accurate data collection related to lung disease monitoring.
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