AI Article Synopsis
- Homologous recombination (HR) is essential for repairing DNA double-strand breaks (DSBs) and maintaining genomic integrity.
- The methyltransferase SET7 regulates HR-mediated DSB repair by methylating the protein TIP60, which plays a role in gene expression and protein stability.
- The study highlights the interplay between SET7 and LSD1 in modifying TIP60, affecting its function and the efficiency of DSB repair processes.
Article Abstract
The repair of DNA double-strand breaks (DSBs) by homologous recombination (HR) is crucial for maintaining genomic integrity and is involved in numerous fundamental biological processes. Post-translational modifications by proteins play an important role in regulating DNA repair. Here, we report that the methyltransferase SET7 regulates HR-mediated DSB repair by methylating TIP60, a histone acetyltransferase and tumor suppressor involved in gene expression and protein stability. We show that SET7 targets TIP60 for methylation at K137, which facilitates DSB repair by promoting HR and determines cell viability against DNA damage. Interestingly, TIP60 demethylation is catalyzed by LSD1, which affects HR efficiency. Taken together, our findings reveal the importance of TIP60 methylation status by SET7 and LSD1 in the DSB repair pathway. [BMB Reports 2022; 55(11): 541-546].
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9712704 | PMC |
| http://dx.doi.org/10.5483/BMBRep.2022.55.11.080 | DOI Listing |
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