Introduction: Botulism is a potentially fatal neuroparalytic syndrome caused by Clostridium botulinum neurotoxin. The 25% are food-borne botulism cases.
Case Report: We describe a confirmed case of botulism attended in our hospital in September 2020, together with a second case in a patient's relative, suspected but not confirmed by laboratory tests. Clinical presentation consisted on general weakness, bilateral cranial palsy, mydriasis, and rapidly progressive tetraparesis in case 1, involving respiratory and swallowing function so she required hospitalization and support treatment. Non specific and transient symptoms occurred in case 2. SARS-CoV-2 infection was initially suspected in both cases due to pandemic situation in our country, ruled out by negative PCR. When B neurotoxin was detected in stool sample of patient 1 we confirmed the diagnosis of food-borne botulism probably linked to home-made conserved beans.
Conclusion: Early clinical suspicion, together with laboratory and electromyography findings, and support treatment provided at hospital were crucial for favourable outcome. Being aware of this rare syndrom might contribute to its better management.
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http://dx.doi.org/10.33588/rn.7503.2021294 | DOI Listing |
Toxicon
November 2023
Department of Emergency Medicine, First Hospital of Jilin University, No. 1 Xinmin St, Changchun, Jilin Province, China. Electronic address:
Food-borne botulism is a rare but potentially fatal illness. Its management depends on rapid diagnosis and prompt antitoxin administration. However, diagnosing food-borne botulism can be challenging at an early stage.
View Article and Find Full Text PDFEuro Surveill
October 2023
Medical Intensive Care Unit, CHU Bordeaux, Bordeaux, France.
Microbiol Spectr
September 2023
Reference and Research Laboratory for Taxonomy, National Centre of Microbiology, Instituto de Salud Carlos III, Majadahonda , Madrid, Spain.
To determine whether the neurotoxin BoNT/B2 causing botulism in Spain is clonal, the genetic diversity and phylogenetic relationships of from food-borne episodes and infant cases of the condition were explored. The botulinum toxin gene () subtype, the variable region of the flagellin gene (VR), and a seven-gene multi-locus sequence type were examined by sequencing 37 BoNT-positive cultures obtained over the period 2010 to 2022. Out of 37 botulism events, 16 food-borne episodes and 16 infant cases were associated with 2.
View Article and Find Full Text PDFAnimals (Basel)
July 2023
S.C. Complex Territorial Diagnostic Structure of Cagliari, Istituto Zooprofilattico Sperimentale of Sardinia, Via Dell'Acquedotto Romano, 09030 Elmas-Cagliari, Italy.
is the main causative agent of botulism in humans and animals. The ingestion of the botulinum neurotoxin, usually types C and D, has been shown to produce disease (neurological symptoms) in most botulism cases in cattle. We report an outbreak in Southern Sardinia that involved a livestock farm with 120 animals, 39 of which died.
View Article and Find Full Text PDFToxins (Basel)
July 2023
French Armed Forces Centre for Epidemiology and Public Health (CESPA), 13014 Marseille, France.
On 6 July 2018, the Center for Epidemiology and Public Health of the French Armed Forces was informed of an outbreak of acute gastroenteritis among customers of a dining facility at a military base in Brittany, France. A total of 200 patients were reported out of a population of 1700 (attack rate: 12%). The symptoms were mainly lower digestive tract disorders and occurred rapidly after lunch on 5 July (median incubation period: 3.
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