AI Article Synopsis
- Circular RNAs (circRNAs) play a role in regulating processes like adipogenesis and can be influenced by single nucleotide polymorphisms (SNPs) associated with BMI.
- The study found that BMI-related SNPs are more commonly located in circRNA genomic regions, especially in females compared to males.
- Further analysis showed that circRNAs are also associated with SNPs in several other health-related traits, indicating that genetic variations may influence BMI via circRNAs.
Article Abstract
Circular RNAs (circRNAs) are regulators of processes like adipogenesis. Their expression can be modulated by SNPs. We analysed links between BMI-associated SNPs and circRNAs. First, we detected an enrichment of BMI-associated SNPs on circRNA genomic loci in comparison to non-significant variants. Analysis of sex-stratified GWAS data revealed that circRNA genomic loci encompassed more genome-wide significant BMI-SNPs in females than in males. To explore whether the enrichment is restricted to BMI, we investigated nine additional GWAS studies. We showed an enrichment of trait-associated SNPs in circRNAs for four analysed phenotypes (body height, chronic kidney disease, anorexia nervosa and autism spectrum disorder). To analyse the influence of BMI-affecting SNPs on circRNA levels in vitro, we examined rs4752856 located on hsa_circ_0022025. The analysis of heterozygous individuals revealed an increased level of circRNA derived from the BMI-increasing SNP allele. We conclude that genetic variation may affect the BMI partly through circRNAs.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314347 | PMC |
| http://dx.doi.org/10.1038/s41598-022-16495-7 | DOI Listing |
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