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Effect of carbonated water on cerebral blood flow in the frontal region: a study using near-infrared spectroscopy.
Front Behav Neurosci
December 2024
Faculty of Science and Technology, Keio University, Yokohama, Japan.
Introduction: Carbonated water (CarbW) affects the swallowing function associated with the action of the brainstem. In addition, CarbW ingestion promotes mean blood flow in the middle cerebral artery, which is associated with blood flow to the frontal and temporal lobes. In this milieu, studies regarding the effect of drinking CarbW on brain activity are of significance.
View Article and Find Full Text PDFExploring the genetic contribution in obesity: An overview of dopaminergic system genes.
Behav Brain Res
March 2025
Human Genetics Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (Fiocruz), 4365 Brazil Avenue, Leônidas Deane Pavilion, Rio de Janeiro, RJ 21040-360, Brazil; Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Professor Rodolpho Paulo Rocco Street, 255, University City, Rio de Janeiro, RJ 21941-617, Brazil. Electronic address:
Article Synopsis
- Obesity is a growing global health issue linked to lower quality of life and higher health risks, with a rising prevalence in Western countries.
- Researchers are investigating the role of neurotransmitters, especially dopamine, in influencing food intake and behaviors associated with obesity.
- Genetic variations affecting dopaminergic processes may contribute to obesity by modifying how the brain responds to food-related rewards, highlighting the importance of understanding genetic factors in managing obesity.
The Potential Role of Dopamine Pathways in the Pathophysiology of Depression: Current Advances and Future Aspects.
CNS Neurol Disord Drug Targets
December 2024
Department of Pharmacology, Delhi Pharmaceutical Sciences & Research University, Delhi 110017, India.
Depression is a serious mental health disorder that impacts more than 350 million individuals globally. While the roles of serotonin and norepinephrine in depression have been extensively studied, the importance of dopaminergic pathways-essential for mood, cognition, motor control, and endocrine function-often gets overlooked. This review focuses on four major dopamine (DA) circuits: the mesolimbic (MLP), mesocortical (MCP), nigrostriatal (NSP), and thalamictuberoinfundibular pathways (TTFP), and their roles in depression.
View Article and Find Full Text PDFLifespan longitudinal changes in mesocortical thickness and executive function: Role of dopaminergic genetic predisposition.
Neurobiol Aging
February 2025
Department of Psychology, School of Behavioral and Brain Sciences, Center for Vital Longevity, The University of Texas at Dallas, 1600 Viceroy Dr, Ste 800, Dallas, TX 75235 USA, United States. Electronic address:
Dopamine (DA) signaling is critical for optimal cognitive aging, especially in prefrontal-parietal and fronto-striatal networks. Single nucleotide polymorphisms associated with dopamine regulation, COMTVal158Met and DRD2C957T, stand to exert influence on executive function performance via neural properties. The current study investigated whether longitudinal thinning of mesocortical regions is related to COMT and DRD2 genetic predisposition and associated with decline in executive function over four-years.
View Article and Find Full Text PDFPossible Potentiating Effects of Combined Administration of Alcohol, Caffeine, and Nicotine on In Vivo Dopamine Release in Addiction-Related Circuits Within the CNS of Rats.
Biomedicines
November 2024
Department of Functional Biology and Health Sciences, Faculty of Biology, University of Vigo, Campus As Lagoas-Marcosende, 36310 Vigo, Spain.
Background: Studies that assess the effects of the interaction of psychoactive substances on dopamine release, the key neurotransmitter in the neurochemical and behavioral effects related to drug consumption, are crucial to understand both their roles and the dysfunctions they produce in the central nervous system.
Objective: We evaluated the effects of individual and combined administration of the three most widely consumed psychoactive substances in the world, ethanol, caffeine, and nicotine, on dopaminergic neurotransmission in three brain regions of rats related to addiction: the prefrontal cortex (PFC), the nucleus accumbens (NAcc), and the dorsal striatum.
Methods: The dopamine levels were measured in vivo by cerebral microdialysis associated with HPLC-ED.
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