Three new glycosylated secondary metabolites, including a new indole alkaloid, pityriacitrin D (), and two new trehalose lipids ( and ), together with three known compounds (-) were isolated from two marine-derived bacterial strains, 168CLC-66.1 and IV19-045. The structures of - were determined by extensive analysis and comparison of their spectroscopic data with literature values. The absolute configurations of sugar moieties were determined by chemical derivatization followed by LC-MS analysis. Cytotoxicity of - against six cancer cell lines was evaluated by SRB assay, and showed moderate activity against all the tested cell lines with GI values ranging from 8.0 to 10.9 µM.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9321207 | PMC |
| http://dx.doi.org/10.3390/md20070464 | DOI Listing |
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