Fucoxanthin is a marine carotenoid found in brown seaweeds and several microalgae. It has been reported that fucoxanthin has health benefits such as anti-obesity and anti-diabetic effects. To facilitate fucoxanthin applications in the food industry, it is important to improve its low bioavailability. We attempted the combined feeding of fucoxanthin-containing seaweed oil (SO) and monocaprin in a powder diet and analyzed the fucoxanthin metabolite contents in the liver, small intestine and serum of diabetic/obese KK- mice. After 4 weeks of feeding with the experimental diets, the serum fucoxanthinol concentrations of the mice fed 0.2% SO and 0.5% monocaprin were higher than those of the 0.2% SO-fed mice. Furthermore, fucoxanthinol accumulation in the liver and small intestine tended to increase in a combination diet of 0.2% SO and 0.125-0.5% monocaprin compared with a diet of 0.2% SO alone, although amarouciaxanthin A accumulation was not different among the 0.2% SO-fed groups. These results suggest that a combination of monocaprin with fucoxanthin-containing SO is an effective treatment for improving the bioavailability of fucoxanthin.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9325202PMC
http://dx.doi.org/10.3390/md20070446DOI Listing

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  • Researchers found that the highest bioaccessibility of fucoxanthin occurred during gastric digestion, along with high antioxidant activity and noticeable color changes.
  • A detailed analysis identified 15 key metabolites, showing a strong correlation between these metabolites, bioaccessibility, antioxidant activity, and color changes, highlighting fucoxanthin's potential benefits as a health food.
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