Protects against PM-Induced Cognitive Dysfunction with the Regulation of Gut Function.

To evaluate the biological effects of (), we tried to confirm the possibility that the intake of could modulate cognitive and intestinal functions in PM-induced cognitive decline mice. attenuated PM-induced learning and memory impairment through antioxidant and anti-inflammatory effects by regulating the mitochondrial function and TLR-initiated NF-κB signaling. In addition, effectively alleviated Aβ production/tau phosphorylation by inhibiting the JNK phosphorylation. Also, the bioactive constituents of determined the sulfated galactan, mycosporine-like amino acids (MAAs), and chlorophyll derivatives. Moreover, the bioactive compounds of by gut fermentation protected against gut dysbiosis and intestinal tight junction damage with a decrease in inflammatory response and short-chain fatty acid production. Based on these results, our findings suggest that with sulfated galactan and MAAs is a potential material for cognitive function improvement.