Importance: Epilepsy affects at least 1.2% of the population, with one-third of cases considered to be drug-resistant epilepsy (DRE). For these cases, focal cooling therapy may be a potential avenue for treatment, offering hope to people with DRE for freedom from seizure. The therapy leverages neuroscience and engineering principles to deliver a reversible treatment unhindered by pharmacology.
Observations: Analogous to (but safer than) the use of global cooling in postcardiac arrest and neonatal ischemic injury, extensive research supports the premise that focal cooling as a long-term treatment for epilepsy could be effective. The potential advantages of focal cooling are trifold: stopping epileptiform discharges, seizures, and status epilepticus safely across species (including humans).
Conclusions And Relevance: This Review presents the most current evidence supporting focal cooling in epilepsy. Cooling has been demonstrated as a potentially safe and effective treatment modality for DRE, although it is not yet ready for use in humans outside of randomized clinical trials. The Review will also offer a brief overview of the technical challenges related to focal cooling in humans, including the optimal device design and cooling parameters.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10101767 | PMC |
| http://dx.doi.org/10.1001/jamaneurol.2022.1936 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Unveiling the Role Reversal of Guest and Host in OverTolerant Hybrid Perovskites.
Small
January 2025
Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhopal, 462 066, India.
The structural and electronic changes are investigated in a 3D hybrid perovskite, methylhydrazinium lead chloride (MHyPbCl) from a host/guest perspective as it transitions from a highly polar to less polar phase upon cooling, using first-principles calculations. The two phases vary structurally in the guest (MHy) orientation and the two differently distorted host (lead halide) layers. These findings highlight the critical role of guest reorientation in reducing host distortion at high temperatures, making the former the primary order parameter for the transition, a notable contrast to the case of other hybrid perovskites.
View Article and Find Full Text PDFStructural Origin of Dynamic Heterogeneity in Supercooled Liquids.
J Phys Chem B
January 2025
Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan.
As a liquid is supercooled toward the glass transition point, its dynamics slow significantly, provided that crystallization is avoided. With increased supercooling, the particle dynamics become more spatially heterogeneous, a phenomenon known as dynamic heterogeneity. Since its discovery, this characteristic of metastable supercooled liquids has garnered considerable attention in glass science.
View Article and Find Full Text PDFCoupling mechanisms of plasmon resonance and Bi3+ emission in YAG: Bi, Ce, Yb epitaxial films at low temperatures.
Sci Rep
January 2025
Institute of Physics, Polish Academy of Sciences, Al. Lotników 32/46, Warsaw, 02-668, Poland.
This paper is devoted to the investigation of the plasmonic effect of metal nanoparticles (NPs) formed on the surface of the YAG: Bi, Ce, Yb phosphors in a temperature range between 4 and 300 K. Combination of a thin conversion layer with silver plasmonic nanostructures leads to increase of sensitizer absorption and emission efficiency. Enhancement of Bi luminescence in YAG epitaxial films with Ag NPs was observed upon cooling the samples below 200 K.
View Article and Find Full Text PDFPlio-Pleistocene Environmental Changes Drove the Settlement of Aotearoa New Zealand by Australian Open-Habitat Bird Lineages.
Mol Ecol
January 2025
Department of Anatomy, University of Otago, Dunedin, New Zealand.
In a changing environment, vacant niches can be filled either by adaptation of local taxa or range-expanding invading species. The relative tempo of these patterns is of key interest in the modern age of climate change. Aotearoa New Zealand has been a hotspot of biogeographic research for decades due to its long-term isolation and dramatic geological history.
View Article and Find Full Text PDFResearch on Wireless Passive Ultrasonic Thickness Measurement Technology Based on Pulse Compression Method.
Sensors (Basel)
December 2024
SINOPEC Research Institute of Safety Engineering Co., Ltd., Qingdao 266000, China.
Fixed-point thickness measurement is commonly used in corrosion detection within petrochemical enterprises, but it suffers from low detection efficiency for localized thinning, limitations regarding measurement locations, and high equipment costs due to insulation and cooling layers. To address these challenges, this paper introduces a wireless passive ultrasonic thickness measurement technique based on a pulse compression algorithm. The research methodology encompassed the development of mathematical and circuit models for single coil and wireless energy transmission, the proposal of a three-terminal wireless energy mutual coupling system, and the establishment of a finite element model simulating the ultrasonic body wave thickness measurement and wireless energy transmission system.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!