AI Article Synopsis
- Senile thymus atrophy contributes to reduced immune function, making it important to repair thymus tissue and restore immune activity in the elderly.
- In a study, elderly macaques were treated with bone marrow mesenchymal stem cells, resulting in increased thymus volume, reduced fibrosis, and signs of tissue regeneration.
- Transcriptomic analysis revealed that after stem cell therapy, the thymus expression patterns in old macaques resembled those of younger ones, suggesting this therapy could prevent or reverse thymus aging.
Article Abstract
Senile thymus atrophy is an important factor leading to decreased immune function. Repairing the atrophic thymus tissue structure, rebuilding immune function, and replenishing the number of exogenous stem cells may be ideal methods. In this study, bone marrow mesenchymal stem cells were intravenously infused into elderly macaques. We found that thymus volume was substantially increased, some thymus tissue regeneration was observed, the degree of thymus tissue fibrosis decreased, collagen fiber deposition decreased, cortical and medulla structures emerged gradually, the number of apoptotic cells decreased significantly, and the expression of apoptosis-related proteins decreased. For the effects of stem cell therapy on aging-related genes, we performed transcriptomic analysis of thymus tissue. The results show the expression pattern of the tissue transcriptome tended to be similar to the thymus expression pattern in young macaques compared with the elderly group, reverse aging-related proteins. Based on the results, it is suggested that stem cell therapy is an ideal method to prevent or reverse the aging of the thymus.
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| http://dx.doi.org/10.1089/rej.2022.0013 | DOI Listing |
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