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Soft tissue sarcomas (STSs) are conventionally viewed as poorly immunogenic tumors; however, some human STSs have recently been reported to elicit an immune response, thus representing potential candidates for immunotherapy. Data regarding immune cell infiltrates in canine STSs are limited and reported without tumor-type stratification. The aim of this study was to retrospectively assess tumor-infiltrating lymphocytes (TILs) in canine STSs of 5 different histotypes.
View Article and Find Full Text PDFCell signaling activation and extracellular matrix remodeling underpin glioma tumor microenvironment heterogeneity and organization.
Cell Oncol (Dordr)
June 2023
Department of Surgery, Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC, Australia.
Purpose: Tumor cells thrive by adapting to the signals in their microenvironment. To adapt, cancer cells activate signaling and transcriptional programs and migrate to establish micro-niches, in response to signals from neighboring cells and non-cellular stromal factors. Understanding how the tumor microenvironment evolves during disease progression is crucial to deciphering the mechanisms underlying the functional behavior of cancer cells.
View Article and Find Full Text PDFT cell-rich perivascular inflammation in a case of cutaneous variant intravascular large B-cell lymphoma.
J Dermatol
December 2022
Department of Dermatology, Hamamatsu University School of Medicine, Shizuoka, Japan.
Myositis with prominent B-cell aggregates causing shrinking lung syndrome in systemic lupus erythematosus: a case report.
BMC Rheumatol
February 2022
Division of Internal Medicine, Department of Medicine, Hôpital du Sacré-Coeur de Montréal, Université de Montréal, 5400 Gouin O Blvd, Montreal, QC, H4J 1C5, Canada.
Background: Shrinking lung syndrome (SLS) is a rare manifestation of systemic lupus erythematosus (SLE) characterized by decreased lung volumes and diaphragmatic weakness in a dyspneic patient. Chest wall dysfunction secondary to pleuritis is the most commonly proposed cause. In this case report, we highlight a new potential mechanism of SLS in SLE, namely diaphragmatic weakness associated with myositis with CD20 positive B-cell aggregates.
View Article and Find Full Text PDFB cell rich meningeal inflammation associates with increased spinal cord pathology in multiple sclerosis.
Brain Pathol
July 2020
Department of Brain Sciences, Faculty of Medicine, Imperial College, London, UK.
Increased inflammation in the cerebral meninges is associated with extensive subpial cortical grey matter pathology in the forebrain and a more severe disease course in a substantial proportion of secondary progressive multiple sclerosis (SPMS) cases. It is not known whether this relationship extends to spinal cord pathology. We assessed the contribution of meningeal and parenchymal immune infiltrates to spinal cord pathology in SPMS cases characterized in the presence (F+) or absence (F-) of lymphoid-like structures in the forebrain meninges.
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