Whether or not the anticancer activity of gambogic acid is achieved regulating the cellular metabolic process remains unclear. Here we report that gambogic acid suppresses the pentose phosphate pathway (PPP) by covalently inhibiting the 6-phosphogluconate dehydrogenase (6PGD) protein. This study elucidates the mechanism of action of gambogic acid from the perspective of metabolic reprogramming regulation in cancer cells.
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| http://dx.doi.org/10.1039/d2cc03069a | DOI Listing |
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