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Identification of a Novel Small RNA Encoded in the Mouse Urokinase Receptor uPAR Gene () and Its Molecular Target . | LitMetric
Urokinase receptor (uPAR) is a glycosylphosphatidylinositol (GPI)-anchored receptor of urokinase (uPA), which is involved in brain development, nerve regeneration, wound healing and tissue remodeling. We have recently shown that , which encodes uPAR, is an early response gene in murine brain. Assumingly, diverse functions of might be attributed to hypothetical, unidentified microRNAs encoded within introns of the gene. Using a bioinformatic approach we identified novel small RNAs within the gene and named them Plaur-miR1-3p and Plaur-miR1-5p. We confirmed -dependent expression of Plaur-miR1-3p and Plaur-miR1-5p in the mouse brain and mouse neuroblastoma Neuro2a cells. Utilizing an algorithm in DianaTools we selected two target genes - and with the highest binding scores to small RNAs selected from identified Plaur-Pre-miR1. Furthermore, sequencing of mouse brain samples for Plaur-miR1-5p target genes revealed two more genes- and . The expression of , and in the mouse brain and and in Neuro2a cells correlated with expression of and small RNAs-Plaur-miR1-3p and Plaur-miR1-5p. Finally, we demonstrated elevated MEF2D protein expression in the mouse brain after induction and displayed activating effects of Plaur-miR1-5p on expression in Neuro2a cells using Luciferase reporter assay. In conclusion, we have identified Plaur-miR1-3p and Plaur-miR1-5p as novel small RNAs encoded in the gene. This finding expands the current understanding of function in brain development and functioning.
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