Background: Three-dimensional (3D) printed guides are finding increasing applications in the field of orthopaedic surgery and more recently spine surgery. This retrospective cohort study compares benefits and costs of 3D printed guides in surgical treatment of adolescent idiopathic scoliosis (AIS) compared to freehand techniques.
Methods: Intraoperative screw placement was conducted either with 3D printed guides (3D cohort) or traditional freehand technique (freehand cohort) for AIS patients undergoing spinal fusion at a single institution. Patient and perioperative data include: screw placement time, length of surgery, blood loss, hospital stay, spinal curvature correction, total implant costs and training level of surgical assist. Multivariate analysis assessed for confounding and effect modification. P-values <0.05 were considered significant.
Results: There were 29 patients included in analyses, 18 in the 3D and 11 in the freehand (FH) cohort, for a total of 263 3D and 307 freehand screws. Between cohorts, there were no significant differences in patient age (P=0.93), gender (P=0.15), height (P=0.18) or weight (P=0.40). The 3D cohort (mean $26,215, SD =$6,374) had significantly higher implant costs than FH (mean $18,660, SD =$5,587, P=0.003) with significantly reduced intraoperative blood loss (mean 559 mL, SD =273 FH; mean 357 mL, SD =123 3D; P=0.01). On multivariate analysis, surgical residents had significantly faster screw placement times when using 3D guides (P<0.001) than when placing screws freehand. There were no significant differences between cohorts in length of postoperative hospitalization, spinal levels fused, or coronal or sagittal curve correction.
Conclusions: At significant cost, 3D printed guides reduce intraoperative blood loss compared to freehand pedicle screw placement and reduce screw placement time for surgical residents.
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http://dx.doi.org/10.21037/jss-22-28 | DOI Listing |
Objective: The aim of this study is to test the feasibility of a custom 3D-printed guide for performing a minimally invasive cochleostomy for cochlear implantation.
Study Design: Prospective performance study.
Setting: Secondary care.
STAR Protoc
January 2025
Department of Medicine, Division of Hematology, Oncology, and Transplantation, University of Minnesota Medical School, Minneapolis, MN, USA; Masonic Cancer Center, University of Minnesota Medical School, Minneapolis, MN, USA. Electronic address:
Tumor Treating Fields (TTFields) are electric fields clinically approved for cancer treatment, delivered via arrays attached to the patient's skin. Here, we present a protocol for applying TTFields to torso orthotopic and subcutaneous mouse tumor models using the inovivo system. We guide users on proper system component connections, study protocol design, mouse fur depilation, array application, and treatment condition adjustment and monitoring.
View Article and Find Full Text PDFActa Neurochir (Wien)
January 2025
Division of Neurosurgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 110 Francis Street , Boston, MA, 02215, USA.
Background: Variability in long-term endovascular treatment outcomes for intracranial aneurysms has prompted questions regarding the effects of these treatments on aneurysm hemodynamics. Endovascular techniques disrupt aneurysmal blood flow and shear, but their influence on intra-aneurysmal pressure remains unclear. A better understanding of aneurysm pressure effects may aid in predicting outcomes and guiding treatment decisions.
View Article and Find Full Text PDFBackground: Emergency department (ED) encounters are often the only healthcare provider encounter for patients seeking care after a reported sexual assault (SA), making the encounter a crucial opportunity to connect patients to support services in the community. An opportunity existed at an urban Level II trauma center to standardize SA discharge planning.
Aims: This quality improvement project aimed to improve access to SA support services.
Alzheimers Dement
December 2024
University of Pennsylvania, Philadelphia, PA, USA
Background: Histopathological analysis of autopsied brains is the gold standard of diagnosis in neurodegenerative disorders. Co‐registered histology and MRI scans aid in understanding pathology and structural features. Previous studies focused on the medial temporal lobe (MTL) for atrophy patterns in phosphorylated tau (p‐tau) pathology and in whole hemisphere scans with contralateral semi‐quantitative p‐tau measures.
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