We propose a theory for preventing instabilities and inducing controlled, slow-slip in frictionally unstable systems, such as the Generalized-Burridge-Knopoff (GBK) model and seismic fault models. We exploit the dependence of friction on pressure and use it as a backdoor for altering the dynamics of the underlying dynamical system. We use the mathematical Theory of Control and, for the first time, we manage to (a) stabilize and restrict chaos in this kind of systems, (b) guarantee slow frictional dissipation and (c) tune the system toward desirable global asymptotic equilibria of lower energy. Our control approach is robust and does not require exact knowledge of the frictional or elastic behavior of the system. Numerical examples of control are given for a Burridge-Knopoff system and a strike-slip fault model obeying rate-and-state friction. GBK models are known to present Self-Organized Critical (SOC) behavior. Therefore, the presented methodology shows an additional example of SOC Control. Even though further developments are necessary before any practical application, we expect our methodology to inspire earthquake mitigation strategies regarding anthropogenic and/or natural seismicity.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9290888 | PMC |
http://dx.doi.org/10.1029/2021JB023410 | DOI Listing |
Nat Cell Biol
January 2025
Department of Biochemistry, University of Oxford, Oxford, UK.
Delays in mitosis trigger p53-dependent arrest in G1 of the next cell cycle, thus preventing repeated cycles of chromosome instability and aneuploidy. Here we show that MDM2, the p53 ubiquitin ligase, is a key component of the timer mechanism triggering G1 arrest in response to prolonged mitosis. This timer function arises due to the attenuation of protein synthesis in mitosis.
View Article and Find Full Text PDFNat Cancer
January 2025
Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
Human tumors are diverse in their natural history and response to treatment, which in part results from genetic and transcriptomic heterogeneity. In clinical practice, single-site needle biopsies are used to sample this diversity, but cancer biomarkers may be confounded by spatiogenomic heterogeneity within individual tumors. Here we investigate clonally expressed genes as a solution to the sampling bias problem by analyzing multiregion whole-exome and RNA sequencing data for 450 tumor regions from 184 patients with lung adenocarcinoma in the TRACERx study.
View Article and Find Full Text PDFAim: To evaluate characteristics of atherosclerotic plaques (ASP) remaining after percutaneous coronary intervention (PCI) in patients with acute coronary syndrome (ACS) by coronary computed tomography angiography (CCTA).
Material And Methods: Among 249 patients (193 men) with ACS aged 58±10 years, 183 (73.5%) had myocardial infarction, 66 (26.
Alzheimers Dement
December 2024
University of Buenos Aires, Buenos Aires, Argentina.
Background: Increasing evidence points to the possible risk roles of psychosocial factors (lack of education, active social participation, physical exercise and mentally stimulating activity, economic instability, traumatic life events) in the pathogenic process and clinical manifestation of dementia disorders. In recent years in our country, in the context of a complex inflationary process, there has been an increase in all indicators of vulnerability and poverty, exceeding 40% of the population below the poverty line in 2023 and around 9% below the indigence line.
Method: In the context of International Alzheimer's Day, the Alzheimer's Disease Awareness Week was held at the Hospital de Clínicas of Buenos Aires.
Research (Wash D C)
January 2025
Cancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Numerous diseases have been connected to protein arginine methylations mediated by protein arginine methyltransferase 5 (PRMT5). Clinical investigations of the PRMT5-specific inhibitor GSK3326595 are currently being conducted, and the results are promising for preventing cancers. However, the detailed mechanism of PRMT5 promoting colorectal cancer (CRC) malignant progression remains unclear.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!